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Current characteristics of hemophilia patients co?infected with HIV/HCV in Japan
http://hdl.handle.net/10069/38297
http://hdl.handle.net/10069/3829746e81ed7-3468-4849-8aae-f89bf0b2daec
名前 / ファイル | ライセンス | アクション |
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ETM15_2148.pdf (598.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-09-01 | |||||
タイトル | ||||||
タイトル | Current characteristics of hemophilia patients co?infected with HIV/HCV in Japan | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hemophilia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hepatitis C virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human immunodeficiency virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Livercirrhosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miuma, Satoshi
× Miuma, Satoshi× Hidaka, Masaaki× Takatsuki, Mitsuhisa× Natsuda, Koji× Soyama, Akihiko× Miyaaki, Hisamitsu× Kanda, Yasuko× Tamada, Yoko× Shibata, Hidetaka× Ozawa, Eisuke× Taura, Naota× Eguchi, Susumu× Nakao, Kazuhiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Over 30 years have passed since co-infection with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) was first documented in hemophilia patients in Japan. In such cases, the leading cause of mortality is reportedly HCV-associated end-stage liver disease. However, the current characteristics of hemophilia patients co-infected with HIV/HCV are unknown. The aim of the present study was to reveal the current characteristics, notably HCV geno-prevalence and liver function, among hemophilia patients co-infected with HIV/HCV in Japan. Current characteristics were evaluated using cross-sectional retrospective data of 44 hemophilia patients positive for anti-HCV and anti-HIV antibodies who underwent screening of liver dysfunction. A total of 56.8% of hemophilia patients co-infected with HIV/HCV were positive for HCV RNA. The most common HCV genotypes were 1a, 1b and 3a. Liver cirrhosis was diagnosed in 26.3% patients negative for HCV RNA and 60.0% patients positive for HCV RNA. Decompensated liver cirrhosis was diagnosed in 33.3% HCV RNA-positive patients and none of the HCV RNA-negative patients. The rate of liver cirrhosis was greater for HCV genotype 3a compared with other genotypes. Overall, the current primary HCV RNA genotypes among hemophilia patients co-infected with HIV/HCV are 1a, 1b and 3a. Over 50% of HIV/HCV co-infected hemophilia patients positive for HCV RNA were diagnosed with liver cirrhosis and some were diagnosed with decompensated liver cirrhosis. | |||||
書誌情報 |
Experimental and Therapeutic Medicine 巻 15, 号 2, p. 2148-2155, 発行日 2018-02 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17920981 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17921015 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/etm.2017.5603 | |||||
権利 | ||||||
権利情報 | c 2018, Spandidos Publications. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experimental and Therapeutic Medicine, 15(2), pp.2148-2155; 2018 |