WEKO3
アイテム
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Adoptive transfer of antithyrotropin receptor (TSHR) autoimmunity from TSHR knockout mice to athymic nude mice
http://hdl.handle.net/10069/29075
http://hdl.handle.net/10069/290759fc17e6e-ee80-40b2-937b-77e7189719bb
名前 / ファイル | ライセンス | アクション |
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Endo153_2034.pdf (697.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-02 | |||||
タイトル | ||||||
タイトル | Adoptive transfer of antithyrotropin receptor (TSHR) autoimmunity from TSHR knockout mice to athymic nude mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytotoxic T lymphocyte antigen 4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nterleukin 2 receptor alpha | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | programmed death 1 ligand 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid stimulating immunoglobulin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyrotropin receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyrotropin receptor antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroxine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adenovirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adipose tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adoptive transfer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal experiment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antibody detection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antibody titer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell infiltration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | controlled study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endocrine ophthalmopathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | extraocular muscle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | female | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | histopathology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hormone blood level | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hyperthyroidism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypothyroidism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immune response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | knockout mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nonhuman | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nude mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | orbit inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | regulatory T lymphocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spleen cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cell depletion | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakahara, Mami
× Nakahara, Mami× Johnson, Kristian× Eckstein, Anja× Taguchi, Ryo× Yamada, Masanobu× Abiru, Norio× Nagayama, Yuji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have recently shown that wild type mice are highly tolerant, whereas thyrotropin receptor (TSHR) knockout (KO) mice are susceptible to immunization with the mouse TSHR, the autoantigen in Graves' disease. However, because TSHR KO mice lack the endogenous TSHR, Graves-like hyperthyroidism cannot be expected to occur in these mice. We therefore performed adoptive transfer of splenocytes from TSHR KO mice into nude mice expressing the endogenous TSHR. Anti-TSHR autoantibodies were detected in approximately 50% recipient mice 4 wk after adoptive transfer of splenocytes (5 × 10 7/mouse) from TSHR KO mice immunized with adenovirus expressing mTSHR A subunit and persisted for 24 wk. Depletion of regulatory T cells by anti-CD25 antibody in the donor mice increased successful transfer rates without increasing antibody levels. Some recipient mice showed transient increases in thyroid-stimulating antibodies and T4 levels 4-8 wk after transfer, but many became thyroid-blocking antibody positive and hypothyroid 24 wk later. Adoptive transfer of splenocytes from naïve TSHR KO mice transiently induced very low antibody titers when the recipient mice were treated with anticytotoxic lymphocyte antigen 4 and antiprogrammed cell death 1 ligand 1 antibodies for 8 wk after transfer. Histologically, macrophages infiltrated the retrobulbar adipose tissues and extraocular muscles in a small fraction of the recipients. Our findings demonstrate successful adoptive transfer of anti-TSHR immune response from TSHR KO mice to nude mice. Although the recipient mice developed only transient and infrequent hyperthyroidism, followed by eventual hypothyroidism, induction of orbital inflammation suggests the possible role of anti-TSHR immune response for Graves' orbitopathy. | |||||
書誌情報 |
Endocrinology 巻 153, 号 4, p. 2034-2042, 発行日 2012-04-01 |
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出版者 | ||||||
出版者 | The Endocrine Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00137227 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1210/en.2011-1846 | |||||
権利 | ||||||
権利情報 | Copyright © 2012 by The Endocrine Society. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Endocrinology, 153(4), pp.2034-2042; 2012 |