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Selenoprotein L-inspired nano-vesicular peroxidase mimics based on amphiphilic diselenides
http://hdl.handle.net/10069/38329
http://hdl.handle.net/10069/383297c3352c8-4809-49f3-af8a-e8d2c0ee29f6
名前 / ファイル | ライセンス | アクション |
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CSB162_172.pdf (528.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-01 | |||||
タイトル | ||||||
タイトル | Selenoprotein L-inspired nano-vesicular peroxidase mimics based on amphiphilic diselenides | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diselenide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liposome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peroxidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Selenium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Selenoprotein L. | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Uehara, Wataru
× Uehara, Wataru× Yoshida, Sakura× Emaya, Yui× Fuchigami, Takeshi× Haratake, Mamoru× Nakayama, Morio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we developed selenoprotein L-inspired nano-vesicular peroxidase mimics based on amphiphilic diselenides. Selenocystine (SeCyst) was used as the starting material for the synthesis of four liposomal membrane-compatible diselenide derivatives (R?Se?Se?R’) with two hydrophobic tails and a polar part. The diselenide derivatives were successfully incorporated into the phosphatidylcholine (PC)-based nano-vesicular scaffold. The results of the particle diameter and zeta-potential measurements suggested that the functional diselenide moiety was placed around the outer surface, not in the hydrophobic interior, of the liposomal membrane structures. The GPx-like catalytic activity of the diselenide/PC liposomes was determined by the conventional NADPH method using glutathione as the reducing substrate. For three peroxide substrates, i.e., hydrogen peroxide, organic tert-butyl hydroperoxide and cummen hydroperoxide, the cationic property-possessing diselenide derivatives in the PC-based liposomes resulted in a higher catalytic activity in comparison to electrically neutral and anionic derivatives. Overall, the diselenide derivatives at the surface of a liposomal colloidal scaffold could exert a GPx-like catalytic activity in physiological aqueous media. | |||||
書誌情報 |
Colloids and Surfaces B: Biointerfaces 巻 162, p. 172-178, 発行日 2018-02-01 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09277765 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.colsurfb.2017.11.063 | |||||
権利 | ||||||
権利情報 | c 2017 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Colloids and Surfaces B: Biointerfaces, 162, pp.172-178; 2018 |