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Pathological significance and prognostic roles of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios in clear cell renal cell carcinoma
http://hdl.handle.net/10069/38532
http://hdl.handle.net/10069/3853279e4f3a0-f06d-419a-b3ae-cbdf7e93d9ce
名前 / ファイル | ライセンス | アクション |
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HumPat79_102.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-08-23 | |||||
タイトル | ||||||
タイトル | Pathological significance and prognostic roles of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios in clear cell renal cell carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD57+ cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD68+ cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mast cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prognosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Renal cell carcinoma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakanishi, Hiromi
× Nakanishi, Hiromi× Miyata, Yasuyoshi× Mochizuki, Yasushi× Yasuda, Takuji× Nakamura, Yuichiro× Araki, Kyohei× Sagara, Yuji× Matsuo, Tomohiro× Ohba, Kojiro× Sakai, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The immune system is closely associated with malignant behavior in renal cell carcinoma (RCC). Therefore, understanding the pathological roles of immune cells in tumor stroma is essential to discuss the pathological characteristics of RCC. In this study, the clinical significance of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios were investigated in patients with clear cell RCC. The densities of CD57+, CD68+, and mast cells were evaluated by immunohistochemical techniques in 179 patients. Proliferation index, apoptotic index, and microvessel density were evaluated by using anti?Ki-67, anti?cleaved caspase-3, and anti-CD31 antibodies, respectively. The density of CD57+ cell was negatively correlated with grade, pT stage, and metastasis, although densities of CD68+ cell and mast cell were positively correlated. Ratios of CD68+ cell/CD57+ cell and mast cell/CD57+ cell were significantly correlated with grade, pT stage, and metastasis. Survival analyses showed that the CD68+ cell/CD57+ cell ratio was a significant predictor for cause-specific survival by multivariate analyses (hazard ratio = 1.41, 95% confidence interval = 1.03-1.93, P =.031) and was significantly correlated with proliferation index, apoptotic index, and microvessel density (r =.47, P <. 001; r = ?.31, P <.001; and r =.40, P <.001, respectively). In conclusion, CD57+ cells, CD68+ cells, and mast cells played important roles in malignancy in clear cell RCC. The CD68+ cell/CD57+ cell ratio was strongly correlated with pathological features and prognosis in these patients because this ratio reflected the status of cancer cell proliferation, apoptosis, and angiogenesis. | |||||
書誌情報 |
Human Pathology 巻 79, p. 102-108, 発行日 2018-09 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00468177 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.humpath.2018.05.007 | |||||
権利 | ||||||
権利情報 | c 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Human Pathology, 79, pp.102-108; 2018 |