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Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma.
http://hdl.handle.net/10069/25081
http://hdl.handle.net/10069/25081385a8e99-e996-47be-934e-9cd616312e32
名前 / ファイル | ライセンス | アクション |
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CanLet303_84.pdf (912.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-05-17 | |||||
タイトル | ||||||
タイトル | Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CRKII | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Invasion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Metastasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oral squamous cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RNA interference | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamada, Shin-Ichi
× Yamada, Shin-Ichi× Yanamoto, Souichi× Kawasaki, Goro× Rokutanda, Satoshi× Yonezawa, Hisanobu× Kawakita, Akiko× Nemoto, Takayuki K |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | CT10 regulator of kinase (CRK) was originally identified as an oncogene product of v-CRK in a CT10 chicken retrovirus system. Overexpression of CRKII has been reported in several human cancers. CRKII regulates cell migration, morphogenesis, invasion, phagocytosis, and survival; however, the underlying mechanisms are not well understood. In the present study, we evaluated the possibility of CRKII as an appropriate molecular target for cancer gene therapy. The expression of CRKII in 71 primary oral squamous cell carcinomas and 10 normal oral mucosal specimens was determined immunohistochemically, and the correlation of CRKII overexpression with clinicopathological factors was evaluated. Overexpression of CRKII was detected in 41 of 70 oral squamous cell carcinomas, the frequency being more significant than in normal oral mucosa. In addition, CRKII overexpression was more frequent in higher-grade cancers according to the T classification, N classification, and invasive pattern. Moreover, RNAi-mediated suppression of CRKII expression reduced the migration and invasion potential of an oral squamous cell carcinoma cell line, OSC20. Downregulation of CRKII expression also reduced the expression of Dock180, p130Cas, and Rac1, and the actin-associated scaffolding protein cortactin. These results indicate that the overexpression of CRKII is tightly associated with an aggressive phenotype of oral squamous cell carcinoma. Therefore, we propose that CRKII could be a potential molecular target of gene therapy by RNAi-targeting in oral squamous cell carcinoma. | |||||
書誌情報 |
Cancer Letters 巻 303, 号 2, p. 84-91, 発行日 2011-04-28 |
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出版者 | ||||||
出版者 | Elsevier Ireland Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03043835 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18727980 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00598513 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21339045 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.canlet.2011.01.004 | |||||
権利 | ||||||
権利情報 | copyright © 2011 Published by Elsevier Ireland Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer Letters, 303(2), pp.84-91; 2011 |