WEKO3
アイテム
{"_buckets": {"deposit": "a741debd-0051-4b4a-a093-7710663097a9"}, "_deposit": {"created_by": 2, "id": "13120", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "13120"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00013120", "sets": ["11"]}, "author_link": ["47681", "47677", "47678", "47676", "47675", "47680", "47679"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "600", "bibliographicPageStart": "592", "bibliographicVolumeNumber": "18", "bibliographic_titles": [{"bibliographic_title": "Journal of Hepato-Biliary-Pancreatic Sciences"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND: The aim of this study was to compare the effects of laserphyrin-PDT (L-PDT) on biliary cancer with those of the conventional photosensitizer, photofrin-PDT (P-PDT). METHODS: An animal tumor model was established by inoculation of NOZ cells in 4-week-old male BALB/c mice. The laser light wavelength was set at 630 nm for P-PDT and 660 nm for L-PDT, at a frequency of 10 Hz. Each group received a total energy flux of 60 J/cm(2). The proportion of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling)-positive cells, expression of VEGF (vascular endothelial growth factor) and the PCNA (proliferating cell nuclear antigen)-labeling index (LI) were assessed after PDT. RESULTS: L-PDT had significantly more potent apoptotic effects at 48 and 72 h after light exposure compared with P-PDT (P \u003c 0.001). The mean PCNA-LI was significantly lower in the L-PDT group than the P-PDT group and the index was significantly lower at several time points after PDT (6, 12, 24, 48 and 72 h after laser light exposure) in the L-PDT than P-PDT (P \u003c 0.001 vs. control). The cell proliferative activity was significantly decreased at 12 and 24 h after P-PDT compared with the control (P \u003c 0.001). VEGF expression was significantly higher at 3 h after L-PDT compared with the control (P \u003c 0.05), whereas it was significantly higher at many time points after P-PDT (3, 6, 48 and 72 h; P \u003c 0.05 vs. control). CONCLUSIONS: L-PDT is a better approach for biliary cancer than the conventional P-PDT, based on its potent apoptotic and cytostatic effects.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Journal of Hepato-Biliary-Pancreatic Sciences, 18(4), pp592-600; 2011", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本肝胆膵外科学会"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "21360081", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s00534-011-0377-6", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2011"}, {"subitem_rights": "The original publication is available at www.springerlink.com"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12507209", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "18686974", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "18686982", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_62": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "Japanese Society of Hepato-Biliary-Pancreatic Surgery"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nonaka, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "47675", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nanashima, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "47676", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nonaka, Mihoko"}], "nameIdentifiers": [{"nameIdentifier": "47677", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uehara, Masataka"}], "nameIdentifiers": [{"nameIdentifier": "47678", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Isomoto, Hajime"}], "nameIdentifiers": [{"nameIdentifier": "47679", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nonaka, Yoshikazu"}], "nameIdentifiers": [{"nameIdentifier": "47680", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagayasu, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "47681", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JHBPS18_592.pdf", "filesize": [{"value": "701.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 701900.0, "url": {"label": "JHBPS18_592.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/13120/files/JHBPS18_592.pdf"}, "version_id": "1b9c0f08-badb-4dd9-9dce-043d14b9e046"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Apoptosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bile duct carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Laserphyrin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Local ablation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Photodynamic therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma."}]}, "item_type_id": "2", "owner": "2", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/27417", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-08-01"}, "publish_date": "2012-08-01", "publish_status": "0", "recid": "13120", "relation": {}, "relation_version_is_last": true, "title": ["Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma."], "weko_shared_id": -1}
Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma.
http://hdl.handle.net/10069/27417
http://hdl.handle.net/10069/2741729b8319a-554f-47e3-8525-e570bc05cd3e
名前 / ファイル | ライセンス | アクション |
---|---|---|
JHBPS18_592.pdf (701.9 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2012-08-01 | |||||
タイトル | ||||||
タイトル | Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bile duct carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Laserphyrin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Local ablation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Photodynamic therapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nonaka, Takashi
× Nonaka, Takashi× Nanashima, Atsushi× Nonaka, Mihoko× Uehara, Masataka× Isomoto, Hajime× Nonaka, Yoshikazu× Nagayasu, Takeshi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: The aim of this study was to compare the effects of laserphyrin-PDT (L-PDT) on biliary cancer with those of the conventional photosensitizer, photofrin-PDT (P-PDT). METHODS: An animal tumor model was established by inoculation of NOZ cells in 4-week-old male BALB/c mice. The laser light wavelength was set at 630 nm for P-PDT and 660 nm for L-PDT, at a frequency of 10 Hz. Each group received a total energy flux of 60 J/cm(2). The proportion of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling)-positive cells, expression of VEGF (vascular endothelial growth factor) and the PCNA (proliferating cell nuclear antigen)-labeling index (LI) were assessed after PDT. RESULTS: L-PDT had significantly more potent apoptotic effects at 48 and 72 h after light exposure compared with P-PDT (P < 0.001). The mean PCNA-LI was significantly lower in the L-PDT group than the P-PDT group and the index was significantly lower at several time points after PDT (6, 12, 24, 48 and 72 h after laser light exposure) in the L-PDT than P-PDT (P < 0.001 vs. control). The cell proliferative activity was significantly decreased at 12 and 24 h after P-PDT compared with the control (P < 0.001). VEGF expression was significantly higher at 3 h after L-PDT compared with the control (P < 0.05), whereas it was significantly higher at many time points after P-PDT (3, 6, 48 and 72 h; P < 0.05 vs. control). CONCLUSIONS: L-PDT is a better approach for biliary cancer than the conventional P-PDT, based on its potent apoptotic and cytostatic effects. | |||||
書誌情報 |
Journal of Hepato-Biliary-Pancreatic Sciences 巻 18, 号 4, p. 592-600, 発行日 2011-07 |
|||||
出版者 | ||||||
出版者 | 日本肝胆膵外科学会 | |||||
出版者別言語 | ||||||
Japanese Society of Hepato-Biliary-Pancreatic Surgery | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18686974 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18686982 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12507209 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21360081 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00534-011-0377-6 | |||||
権利 | ||||||
権利情報 | © Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2011 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Hepato-Biliary-Pancreatic Sciences, 18(4), pp592-600; 2011 |