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In April 2015, the classification of “Foods with Function Claims” was introduced in Japan to make more products available to the public that were \nclearly labeled with functional claims based on scientific evidence. In order to obtain recognition of ACAPOLIA PLUS under this new classification, the following information needed to be established. The safety of the bark extract of Acacia mearnsii was shown from the history of the long-term safe \nconsumption of the extract as a health supplement, together with several additional clinical safety tests. Robinetinidol-(4α,8)-catechin was detected by high performance liquid chromatography (HPLC) in the supplement and was suitable for use as the basis of the quantitative analysis. 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Utilization of Flavonoid Compounds from Bark and Wood. III. Application in Health Foods
http://hdl.handle.net/10069/38596
http://hdl.handle.net/10069/385960fd20ee2-246d-48a8-b63c-867b58e328cf
名前 / ファイル | ライセンス | アクション |
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molecules23_1860.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-09-26 | |||||
タイトル | ||||||
タイトル | Utilization of Flavonoid Compounds from Bark and Wood. III. Application in Health Foods | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acacia mearnsii bark | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Foods with function claims | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Functional substance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Health foods | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proanthocyanidins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wattle tannin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ogawa, Sosuke
× Ogawa, Sosuke× Matsuo, Yosuke× Tanaka, Takashi× Yazaki, Yoshikazu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dietary supplements ACAPOLIAR and ACAPOLIA PLUS have been sold in Japan under the classification “Foods in General” for a number of years. In April 2015, the classification of “Foods with Function Claims” was introduced in Japan to make more products available to the public that were clearly labeled with functional claims based on scientific evidence. In order to obtain recognition of ACAPOLIA PLUS under this new classification, the following information needed to be established. The safety of the bark extract of Acacia mearnsii was shown from the history of the long-term safe consumption of the extract as a health supplement, together with several additional clinical safety tests. Robinetinidol-(4α,8)-catechin was detected by high performance liquid chromatography (HPLC) in the supplement and was suitable for use as the basis of the quantitative analysis. In clinical tests, the amount of change in the plasma glucose concentration in the initial 60 min after rice consumption by a test group who had been given the Acadia extract was significantly lower than the glucose concentration in the group that was given a placebo. The blood glucose incremental areas under the curve (IAUC) in the first 60 min after rice consumption were also significantly lower in the Acacia group. The functional mechanisms were explained in terms of the inhibition of the absorption of glucose in the small intestine and the reduction in the activity of the digestive enzymes caused by proanthocyanidins derived from A. mearnsii bark. As a result, ACAPOLIA PLUS was accepted as a “Food with Function Claims” in August 2016. ACAPOLIA PLUS is now sold under this new classification. The growth of a typical intestinal bacterium is inhibited by an extract containing flavonoid compounds from A. mearnsii bark; thus, one of the future directions of study must be a comprehensive investigation of the effect that flavonoid compounds, proanthocyanidins, have on intestinal bacteria. |
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書誌情報 |
Molecules 巻 23, 号 8, p. 1860, 発行日 2018-07-26 |
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出版者 | ||||||
出版者 | MDPI AG | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14203049 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/molecules23081860 | |||||
権利 | ||||||
権利情報 | c 2018 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.(CC BY 4.0). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Molecules, 23(8), art.no.1860; 2018 |