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Effect of polyglycolic acid sheets with fibrin glue (MCFP technique) on the healing of wounds after partial resection of the border of the tongue in rabbits: a preliminary study
http://hdl.handle.net/10069/25388
http://hdl.handle.net/10069/253889af5e16f-d04e-48ef-ba1b-e1eaf4a3cdff
名前 / ファイル | ライセンス | アクション |
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BJOMS50_459.pdf (654.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-07-25 | |||||
タイトル | ||||||
タイトル | Effect of polyglycolic acid sheets with fibrin glue (MCFP technique) on the healing of wounds after partial resection of the border of the tongue in rabbits: a preliminary study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polyglycolic acid sheet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fibrin glue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rabbit | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tongue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wound healing | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yonezawa, Hisanobu
× Yonezawa, Hisanobu× Yamada, Shin-ichi× Yanamoto, Souichi× Yoshitomi, Izumi× Kawasaki, Goro× Umeda, Masahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to examine the effectiveness of covering wounds to the tongue with a polyglycolic acid (PGA) sheet and fibrin glue. Eighteen mature male Japanese white rabbits had a unilateral glossectomy involving an area 10 mm × 10 mm × 2 mm. After glossectomy the tongues were covered with PGA sheets 8 mm × 8 mm in size and fibrin glue (mucosal defect covered with fibrin glue and polyglycolic acid sheet = MCFP) 1 week after the operation (n = 3), after 2 weeks (n = 3), and after 4 weeks (n = 3). In control groups, after 1, 2, and 4 weeks (n = 3 in each group), the partially resected tongues were closed with absorbable sutures (polyglactin 910). One week (experimental and control groups 1), 2 weeks (experimental and control groups 2) and 4 weeks (experimental and control groups 3) after operation the tongues were harvested and stained for microscopic examination. Histological examination showed that the covered wound surface had not epithelialised and the basal layer had yet to form in experimental group 1, but had formed in experimental group 2. However, in control group 1, epithelialisation of the sutured wound had begun. Immunohistochemical examination showed that, in experimental group 1, the non-uniform epithelial layer of the covered wound surface expressed cytokeratin AE1/AE3, and the epithelial and connective tissue layers stained strongly for FGF-2. Similar results were obtained in experimental group 2, whereas in experimental group 3, FGF-2 was expressed only in the connective tissue layer, and epithelialisation was complete. However, in control group 1, AE1/AE3 was expressed in the epithelial layer, and FGF was expressed in the connective tissue layer beneath the basal layer. In control groups 2 and 3, AE1/AE3 and FGF-2 were expressed in patterns similar to those in experimental groups 2 and 3. We suggest that this method is useful and the operation is simple. However, further testing of the method is needed and it should be widely used clinically before it is recommended. | |||||
書誌情報 |
British Journal of Oral and Maxillofacial Surgery 巻 50, 号 5, p. 459-463, 発行日 2012-07 |
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出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02664356 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15321940 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10507219 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21820772 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bjoms.2011.07.012 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | British Journal of Oral and Maxillofacial Surgery, 50(5), pp.459-463; 2012 |