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Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus.
http://hdl.handle.net/10069/27424
http://hdl.handle.net/10069/2742488b5730f-2914-4c71-a89f-f57bfacecc3c
名前 / ファイル | ライセンス | アクション |
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ArcVio156_1359.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-09-01 | |||||
タイトル | ||||||
タイトル | Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Influenza A virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PGG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiviral activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mechanisms of action | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Liu, Ge
× Liu, Ge× Xiong, Sheng× Xiang, Yang-Fei× Guo, Chao-Wan× Ge, Feng× Yang, Chong-Ren× Zhang, Ying-Jun× Wang, Yi-Fei× Kitazato, Kaio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Influenza A virus (IAV) infection is a major public health threat leading to significant morbidity and mortality. The emergence of drug-resistant virus strains highlights the urgent need to develop novel antiviral drugs with alternative modes of action. Pentagalloylglucose (PGG), a naturally occurring polyphenolic compound, possesses a broad spectrum of biological activities. In this study, we found that PGG has anti-influenza-virus activity, and investigated its possible mechanism(s) of action in vitro. Both pre-incubation of virus prior to infection and post-exposure of infected cells with PGG significantly inhibited virus yields. Influenza-virus-induced hemagglutination of chicken red blood cells was inhibited by PGG treatment, suggesting that PGG can inhibit IAV infection by interacting with the viral hemagglutinin. PGG did not affect viral protein synthesis or nuclear transport of viral nucleoprotein (NP) but greatly reduced plasma membrane accumulation of NP protein at the late stage of the replication cycle. Furthermore, PGG significantly reduced virus budding and progeny virus release from infected cells. This study revealed for the first time that PGG can inhibit IAV replication with a dual mode of action and offers new insights into its underlying mechanisms of antiviral action. | |||||
書誌情報 |
Archives of virology 巻 156, 号 8, p. 1359-1369, 発行日 2011-08 |
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出版者 | ||||||
出版者 | Springer | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03048608 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14328798 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00548901 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21479599 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00705-011-0989-9 | |||||
権利 | ||||||
権利情報 | © Springer-Verlag 2011 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Archives of virology, 156(8), pp.1359-1369; 2011 |