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The C-terminus of MIP-T3 protein is required for ubiquitin-proteasome-mediated degradation in human cells.
http://hdl.handle.net/10069/25452
http://hdl.handle.net/10069/25452dadbc3fe-44b4-426a-be87-64c8c9656982
名前 / ファイル | ライセンス | アクション |
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FEBS585_1350.pdf (676.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-08-01 | |||||
タイトル | ||||||
タイトル | The C-terminus of MIP-T3 protein is required for ubiquitin-proteasome-mediated degradation in human cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intraflagellar transport | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MIP-T3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polyubiquitination | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proteasome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein ability | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Guo, Chao-Wan
× Guo, Chao-Wan× Liu, Ge× Xiong, Sheng× Ge, Feng× Fuse, Takayuki× Wang, Yi-Fei× Kitazato, Kaio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The intraflagellar transport (IFT) complex is essential for the formation and functional maintenance of eukaryotic cilia which play a vital role in development and tissue homeostasis. However, the biochemical characteristics and precise functions of IFT proteins remain unknown. Here, we report that MIP-T3, a human microtubule-interacting protein recently identified as a novel conserved component of the IFT complex, is an easily degradable protein in human cell lines. Protein degradation is mediated by the ubiquitin-proteasome system, and the C-terminus is required for ubiquitination and proteasome-mediated degradation of MIP-T3 protein. This study provides the first evidence for regulation of IFT protein stability. | |||||
書誌情報 |
FEBS Letters 巻 585, 号 9, p. 1350-1356, 発行日 2011-05-06 |
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出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00145793 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18733468 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00642943 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21510943 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.febslet.2011.04.015 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Federation of European Biochemical Societies Published by Elsevier B.V. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEBS Letters, 585(6), pp.1350-1356; 2011 |