We previously reported that the apoptosis index in jejunal crypt cells after X irradiation was greater in spontaneously hypertensive rats than in Wistar-Kyoto rats. Moreover, these same cells showed a suppression of apoptosis when reserpine was administered to induce sympathetic dysfunction in spontaneously hypertensive rats or Wistar-Kyoto rats.1) Whether the hyperfunction of the sympathetic nervous system is involved in the high susceptibility of the jejunal crypt cells to radiation-induced apoptosis was the subject of this study. The effect of norepinephrine (NE) on cell survival was examined using the colony formation assay after X-ray irradiation of rat ileal epithelial cells (IEC-18). The addition of 1 μM NE decreased the surviving fraction of cells irradiated with 6 Gy from 37% to 8%. The radiosensitivity of IEC-18 cells was enhanced by the addition of 1 μM of NE. The irradiation and treatment with NE also resulted in an increased cellular apoptotic rate. These results showing enhanced radiosensitivity of rat ileal epithelial cells by NE suggest that NE may be one of the factors which aggravate acute radiation injury in the intestine.
雑誌名
Journal of Radiation Research
巻
52
号
3
ページ
369 - 373
発行年
2011-05-31
出版者
Journal of Radiation Research Editorial Committee
出版者別言語
日本放射能影響学会
ISSN
04493060
書誌レコードID
AA00705792@@@AA12023541
DOI
10.1269/jrr.10155
権利
Copyright (c) 2011 by Journal of Radiation Research Editorial Committee
著者版フラグ
publisher
引用
Journal of Radiation Research, 52(3), pp.369-373; 2011
Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells
JRR52_369.pdf
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