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Thalidomide prevents the progression of peritoneal fibrosis in mice.
http://hdl.handle.net/10069/25614
http://hdl.handle.net/10069/256145d8e6fa0-bc90-440a-be42-a2bdc1272b7c
名前 / ファイル | ライセンス | アクション |
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AHC44_51.pdf (796.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-08-31 | |||||
タイトル | ||||||
タイトル | Thalidomide prevents the progression of peritoneal fibrosis in mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PCNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TGF-β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thalidomide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VEGF | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Arai, Hideyuki
× Arai, Hideyuki× Furusu, Akira× Nishino, Tomoya× Obata, Yoko× Nakazawa, Yuka× Nakazawa, Masayuki× Hirose, Misaki× Abe, Katsushige× Koji, Takehiko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Thalidomide is clinically recognized as a therapeutic agent for multiple myeloma and has been known to exert anti-angiogenic actions. Recent studies have suggested the involvement of angiogenesis in the progression of peritoneal fibrosis. The present study investigated the effects of thalidomide on the development of peritoneal fibrosis induced by injection of chlorhexidine gluconate (CG) into the mouse peritoneal cavity every other day for 3 weeks. Thalidomide was given orally every day. Peritoneal tissues were dissected out 21 days after CG injection. Expression of CD31 (as a marker of endothelial cells), proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), α-smooth muscle actin (as a marker of myofibroblasts), type III collagen and transforming growth factor (TGF)-β was examined using immunohistochemistry. CG group showed thickening of the submesothelial zone and increased numbers of vessels and myofibroblasts. Large numbers of VEGF-, PCNA-, and TGF-β-positive cells were observed in the submesothelial area. Thalidomide treatment significantly ameliorated submesothelial thickening and angiogenesis, and decreased numbers of PCNA- and VEGF-expressing cells, myofibroblasts, and TGF-β-positive cells. Moreover, thalidomide attenuated peritoneal permeability for creatinine, compared to the CG group. Our results indicate the potential utility of thalidomide for preventing peritoneal fibrosis. | |||||
書誌情報 |
Acta Histochemica et Cytochemica 巻 44, 号 2, p. 51-60, 発行日 2011-04-28 |
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出版者 | ||||||
出版者 | The Japan Society of Histochemistry and Cytochemistry | |||||
出版者別言語 | ||||||
日本組織細胞化学会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00445991 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475800 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508022 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21614166 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1267/ahc.10030 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2011 By the Japan Society of Histochemistry and Cytochemistry | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/26735 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Histochemica et Cytochemica, 44(2), pp.51-60; 2011 |