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Characterization of waves of leukocyte recruitment to the lung allograft and the effect of CTLA4-Ig
http://hdl.handle.net/10069/25652
http://hdl.handle.net/10069/2565221914db0-a587-4e22-8cce-bff68f0cdd7b
名前 / ファイル | ライセンス | アクション |
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ActMed56_27.pdf (172.3 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2011-09-02 | |||||
タイトル | ||||||
タイトル | Characterization of waves of leukocyte recruitment to the lung allograft and the effect of CTLA4-Ig | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | allograft rejection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD28 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | flow cytometry | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Taguchi, Tsunenori
× Taguchi, Tsunenori× Inamura, Yukio× Honma, Kiri× Kimura, Daisuke× Miyakoda, Mana× Miyazaki, Takuro× Tsuchiya, Tomoshi× Yamasaki, Naoya× Tagawa, Tsutomu× Nagayasu, Takeshi× Yui, Katsuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | MHC-mismatched lung allografts are rapidly rejected by the host immune response. We analyzed cells infiltrating the grafted lung tissue using a collagenase-digestion method. The grafted lung was filled with host-derived leukocytes as early as day 1 post transplantation and the majority of the initial infiltrating cells were granulocytes. This initial influx of granulocytes waned rapidly, followed by a steady increase in lymphocytes, particularly T cells, and then by macrophages. The proportion of CD4+ T cells that express CD25 were increased in the graft the majority of which were activated CD4+ cells. We applied cytotoxic T-lymphocyte-associated antigen 4 (CTLA4)-Ig treatment in combination with donor-specific blood transfusion to the transplantation of lung allograft, which was significantly prolonged by the treatment. To examine the cellular and molecular basis of the inhibition of the graft rejection, we evaluated number and cytokine mRNA expression of the cells infiltrating in the lung allograft using collagenase-digestion method, although we were unable to detect significant effects of the treatment. Taken together, this study demonstrates that single cell suspensions from cellular infiltrates of lung tissue is useful for phenotypical and functional studies on cells infiltrating lung tissue after graft transplantation. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 56, 号 2, p. 27-34, 発行日 2011-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/32659 | |||||
sortkey | ||||||
1 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia, 56(2), pp.27-34; 2011 |