A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and a transbronchial lung biopsy specimen revealed acellular periodic acid-Schiff stain-positive bodies. The serum anti-granulocyte macrophage-colony stimulating factor (GM-CSF) antibody titer was elevated. The diagnosis was autoimmune pulmonary alveolar proteinosis (PAP). There are few reports of autoimmune PAP in patients with ulcerative colitis. Some reports suggest that PAP and inflammatory bowel disease might have a common pathogenesis involving the anti-GM-CSF antibody.
雑誌名
日本内科学会雑誌
巻
57
号
18
ページ
2705 - 2708
発行年
2018-09-15
出版者
日本内科学会
出版者別言語
Japanese Society of Internal Medicine
ISSN
09182918
EISSN
13497235
DOI
10.2169/internalmedicine.0555-17
権利
? 2018 The Japanese Society of Internal Medicine. The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Pulmonary Alveolar Proteinosis with Ulcerative Colitis
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