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Predictive factors of efficacy of combination therapy with basal insulin and liraglutide in type 2 diabetes when switched from longstanding basal-bolus insulin: Association between the responses of β- and α-cells to GLP-1 stimulation and the glycaemic control at 6?months after switching therapy
http://hdl.handle.net/10069/38625
http://hdl.handle.net/10069/38625c0129001-6b09-44cb-900f-6a5a7de8ab7c
名前 / ファイル | ライセンス | アクション |
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DRCP144_161.pdf (493.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-11-01 | |||||
タイトル | ||||||
タイトル | Predictive factors of efficacy of combination therapy with basal insulin and liraglutide in type 2 diabetes when switched from longstanding basal-bolus insulin: Association between the responses of β- and α-cells to GLP-1 stimulation and the glycaemic control at 6?months after switching therapy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Basal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bolus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GLP-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glucagon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liraglutide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proinsulin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Horie, Ichiro
× Horie, Ichiro× Haraguchi, Ai× Sako, Ayaka× Akeshima, Junya× Niri, Tetsuro× Shigeno, Riyoko× Ito, Ayako× Nozaki, Aya× Natsuda, Shoko× Akazawa, Satoru× Mori, Yoshitaka× Ando, Takao× Kawakami, Atsushi× Abiru, Norio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aims: To evaluate the glycaemic control of combination therapy with basal insulin and liraglutide, and to explore the factors predictive of efficacy in patients with type 2 diabetes when switched from longstanding basal-bolus insulin therapy. Methods: We studied 41 patients who switched from basal-bolus insulin therapy of more than 3 years to basal insulin/liraglutide combination therapy. Glycaemic control was evaluated at 6 months after switching therapy and used to subdivide the patients into good-responders (HbA1c <7.0% or 1.0% decrease) and poor-responders (the rest of participants). To evaluate the glucose-dependent insulin/glucagon responses without/with liraglutide, a 75-g oral glucose tolerance test (OGTT) was performed twice, before (1st-OGTT) and 2-days after (2nd-OGTT) liraglutide administration. Results: Twenty-eight patients (68.3%) were identified as good-responders. No differences were found in baseline characteristics including insulin/glucagon responses during 1st-OGTT between the groups. 2nd-OGTT revealed that paradoxical hyperglucagonemia were significantly improved in both groups, but significant increases in insulin secretory response were observed only in good-responders. Logistic regression analyses revealed that the improvement of the insulin-response during 2nd-OGTT compared to that during 1st-OGTT is associated with the good-responder. Conclusions: Enhancement of glucose-dependent insulin-response under liraglutide administration is a potential predictor of long-term glycaemic control after switching the therapies. | |||||
書誌情報 |
Diabetes Research and Clinical Practice 巻 144, p. 161-170, 発行日 2018-10 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01688227 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.diabres.2018.08.015 | |||||
権利 | ||||||
権利情報 | c 2018 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Diabetes Research and Clinical Practice, 144, pp.161-170; 2018 |