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The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages.
http://hdl.handle.net/10069/27432
http://hdl.handle.net/10069/27432b0fe682d-0a68-4fea-b936-d5f3bfc4b04f
名前 / ファイル | ライセンス | アクション |
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Autoimmunity44_504.pdf (263.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-10-01 | |||||
タイトル | ||||||
タイトル | The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NOD mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Regulatory T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sialitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thyroiditis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type 1 diabetes | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakahara, Mami
× Nakahara, Mami× Nagayama, Yuji× Ichikawa, Tatsuki× Yu, Liping× Eisenbarth, George S× Abiru, Norio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The nonobese diabetic (NOD) mouse spontaneously develops several autoimmune diseases, including type 1 diabetes and to a lesser extent thyroiditis and sialitis. Imbalance between effector T cells (Teffs) and regulatory T cells (Tregs) has recently been proposed as a mechanism for the disease pathogenesis in NOD mice, but previous studies have shown the various outcomes by different timing and methods of Treg-depletion. This study was, therefore, designed to compare the consequences of Treg-depletion by the same method (anti-CD25 antibody) on the spectrum of organ-specific autoimmune diseases in NOD mice of different ages. Treg-depletion by anti-CD25 antibody at 10 days of age accelerated development of all three diseases we examined (insulitis/diabetes, thyroiditis, and sialitis); Treg-depletion at 4 weeks of age accelerated only diabetes but not thyroiditis or sialitis; and Treg-depletion at 12 weeks of age hastened only development of thyroiditis and exhibited little influence on diabetes or sialitis. Increased levels of insulin autoantibodies (IAA) were, however, observed in mice depleted of Tregs at 10 days of age, not in those at 4 weeks. Thus, the consequences of Treg-depletion on the spectrum of organ-specific autoimmune diseases depend on the timing of anti-CD25 antibody injection in NOD mice. Aging gradually tips balance between Teffs and Tregs toward Teff-dominance for diabetes, but this balance for thyroiditis and sialitis likely alters more intricately. Our data also suggest that the levels of IAA are not necessarily correlated with diabetes development. | |||||
書誌情報 |
Autoimmunity 巻 44, 号 6, p. 504-510, 発行日 2011-09 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08916934 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1607842X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10707648 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21306188 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/08916934.2010.548839 | |||||
権利 | ||||||
権利情報 | © 2011 Informa UK, Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Autoimmunity, 44(6), pp.504-510; 2011 |