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Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica.
http://hdl.handle.net/10069/27434
http://hdl.handle.net/10069/2743495595150-c7d5-4d01-94ab-83657895b0e7
名前 / ファイル | ライセンス | アクション |
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IntImm23_565.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-10-01 | |||||
タイトル | ||||||
タイトル | Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aquaporin-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD69 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neuromyelitis optica | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proteolipid protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuya, Nemu
× Matsuya, Nemu× Komori, Mika× Nomura, Kyouichi× Nakane, Shunya× Fukudome, Takayasu× Goto, Hirofumi× Shiraishi, Hirokazu× Wandinger, Klaus-Peter× Matsuo, Hidenori× Kondo, Takayuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown to be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated T cells in PBMCs during NMO relapses. Next, T-cell responses to AQP4 and myelin peptides were studied in 12 NM0 patients, 10 multiple sclerosis (MS) patients and 10 healthy subjects (HS). Four hours after adding 1 of 28 overlapping AQP4 peptides, a mixture of AQP4 peptides (AQP4-M) or one of six distinct myelin peptides to 2-day cultured PBMC, CD69 expression on CD4+ T cells was examined. Data were analyzed by paired t-test, frequency of samples with 3-fold increase of CD69 on CD4+ cells (fSI3) and mean stimulation index (mSI). The T-cell response to AQP4-M was significantly increased in NMO (fSI3 = 10/12, mSI = 5.50), with AQP4 (11-30) and AQP4 (91-110) representing the two major epitopes (AQP4 (11-30), fSI3 = 11/12, mSI = 16.0 and AQP4 (91-110), fSI3 = 11/12, mSI = 13.0). Significant but less extensive responses to these two epitopes were also observed in MS and HS. Significant reactivities against AQP4 (21-40), AQP4 (61-80), AQP4 (101-120), AQP4 (171-190) and AQP4 (211-230) were exclusively found in NMO. In addition, responses to AQP4 (81-100) were higher and more frequently detected in NMO, without reaching statistical significance. Interestingly, among the six myelin peptides studied, proteolipid protein (95-116) induced a significant T-cell response in NMO (fSI3 = 7/12, mSI = 4.60). Our study suggests that cellular as well as humoral responses to AQP4 are necessary for NMO development and that the immune response to myelin protein may contribute to disease pathogenesis. | |||||
書誌情報 |
International Immunology 巻 23, 号 9, p. 565-573, 発行日 2011-09 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09538178 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14602377 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10730708 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21795759 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/intimm/dxr056 | |||||
権利 | ||||||
権利情報 | © The Japanese Society for Immunology. 2011. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com | |||||
権利 | ||||||
権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version International Immunology, 23(9), pp.565-573; 2011 is available online at: http://intimm.oxfordjournals.org/content/23/9/565. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Immunology, 23(9), pp.565-573; 2011 |