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However, the genetic factors that are associated with short stature and dyslipidemia in subjects with a low BMI are unknown. \nMethods: We conducted a cross-sectional study of 877 elderly Japanese subjects aged ?60 years who underwent a national health check-up in 2014 and 2015. We focused on single nucleotide polymorphism (SNP) rs3782886, since this variant was reported to be associated with metabolic syndrome. Short stature was defined as the lowest 20% of the height distribution (\u003c157.8cm for men and \u003c145.0cm for women), and dyslipidemia was defined by the Japan Atherosclerosis Society (JAS) guidelines as follows: \ntriglycerides (TG) ?150mg/dL and/or low density lipoprotein-cholesterol (LDL) ?140mg/dL, and/or high density lipoproteincholesterol (HDL) \u003c40mg/dL, and/or lipid lowering medication use. Results: Of the study population, 62.3% were major homo, 33.0% were hetero and 4.8% minor homo. 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Single nucleotide polymorphism as an indicator of short stature and dyslipidemia in community-dwelling elderly Japanese subjects
http://hdl.handle.net/10069/38668
http://hdl.handle.net/10069/3866880582432-7b2d-4f90-a752-885d37e218b0
名前 / ファイル | ライセンス | アクション |
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ActMed62_7.pdf (563.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-10-30 | |||||
タイトル | ||||||
タイトル | Single nucleotide polymorphism as an indicator of short stature and dyslipidemia in community-dwelling elderly Japanese subjects | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Body mass index | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dyslipidemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rs3782886 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | short stature | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SNP | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Tezuka, Kazuhide
× Tezuka, Kazuhide× Shimizu, Yuji× Noguchi, Yuko× Sato, Shimpei× Koyamatsu, Jun× Yamanashi, Hirotomo× Nagayoshi, Mako× Kawashiri, Shin-Ya× Nagata, Yasuhiro× Maeda, Takahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aims: We previously reported an inverse association between adult height and dyslipidemia in subjects with low, but not high, body mass index (BMI) by elucidating genetic influences. However, the genetic factors that are associated with short stature and dyslipidemia in subjects with a low BMI are unknown. Methods: We conducted a cross-sectional study of 877 elderly Japanese subjects aged ?60 years who underwent a national health check-up in 2014 and 2015. We focused on single nucleotide polymorphism (SNP) rs3782886, since this variant was reported to be associated with metabolic syndrome. Short stature was defined as the lowest 20% of the height distribution (<157.8cm for men and <145.0cm for women), and dyslipidemia was defined by the Japan Atherosclerosis Society (JAS) guidelines as follows: triglycerides (TG) ?150mg/dL and/or low density lipoprotein-cholesterol (LDL) ?140mg/dL, and/or high density lipoproteincholesterol (HDL) <40mg/dL, and/or lipid lowering medication use. Results: Of the study population, 62.3% were major homo, 33.0% were hetero and 4.8% minor homo. With non-minor homo (major homo and hetero) as reference groups, minor homo was significantly positively associated with short stature independent of known cardiovascular risk factors. The multivariable odds ratio (OR) and 95% confidence interval (CI) of short stature for minor homo was 2.23 (1.07, 4.67). Minor homo also showed a significant positive association with dyslipidemia in subjects with a BMI<23kg/m2, 3.20 (1.08, 9.51), but not in those with a BMI?23kg/m2 ,0.77 (0.32, 1.89). Conclusion: SNP rs3782886 is associated with short stature and dyslipidemia in elderly Japanese subjects with a BMI<23kg/m2. |
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書誌情報 |
Acta medica Nagasakiensia 巻 62, 号 1, p. 7-14, 発行日 2018-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
02 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 62(1), pp.7-14; 2018 |