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Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: A multicenter trial in Japan.
http://hdl.handle.net/10069/24110
http://hdl.handle.net/10069/24110dd52c37e-3e6b-4629-baf1-857866e24bee
名前 / ファイル | ライセンス | アクション |
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JouInf_Izumikawa.pdf (637.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-10-07 | |||||
タイトル | ||||||
タイトル | Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: A multicenter trial in Japan. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic pulmonary aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Micafungin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Voriconazole | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kohno, Shigeru
× Kohno, Shigeru× Izumikawa, Koichi× Ogawa, Kenji× Kurashima, Atsuyuki× Okimoto, Niro× Amitani, Ryoichi× Kakeya, Hiroshi× Niki, Yoshihito× Miyazaki, Yoshitsugu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chronic pulmonary aspergillosis (CPA) is slowly progressive inflammatory pulmonary syndrome due to Aspergillus spp. The evidence regarding CPA treatment is limited. We conducted a randomized, multicenter, open-label trial comparing intravenous micafungin (MCFG) of 150-300 mg once daily with intravenous voriconazole (VRCZ) of 6 mg/kg twice on Day 1 followed by 4 mg/kg twice daily for the treatment of 107 in patients with CPA to compare the efficacy and safety of both drugs as initial treatment in Japan. Treatment effectiveness was defined by clinical, mycological, radiological and serological responses 2 weeks after the initial administration and at the end of therapy. The total of 50 and 47 patients were assigned to the MCFG and VRCZ groups, respectively. The difference in efficacy rates between MCFG and VRCZ was not significant, either after 2 weeks [68.0% vs. 58.7%; the absolute difference, 9.3% with a 95% confidence interval (CI), -9.97 to 28.58, P = 0.344] or at the end of therapy (60.0% vs. 53.2%; the absolute difference, 6.8% with a 95% CI, -12.92 to 26.54, P = 0.499). In the safety evaluation, fewer adverse events occurred in the MCFG than VRCZ group (26.4% vs. 61.1%, P = 0.0004). MCFG was as effective as VRCZ and significantly safer than as an initial treatment of CPA. (UMIN Clinical Trials Registry number, UMIN000001786.). | |||||
書誌情報 |
The Journal of infection 巻 61, 号 5, p. 410-418, 発行日 2010-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01634453 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15322742 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00258231 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20797407 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jinf.2010.08.005 | |||||
権利 | ||||||
権利情報 | Copyright © 2010 The British Infection Society Published by Elsevier Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of infection, 61(5), pp.410-418; 2010 |