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Muscle-specific tyrosine kinase-antibody-positive myasthenic crisis with detailed electrophysiologic studies.
http://hdl.handle.net/10069/22945
http://hdl.handle.net/10069/229454bcf7291-14bc-41ec-b772-f0b4d540522d
名前 / ファイル | ライセンス | アクション |
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AJEM27_754.e5.pdf (108.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-18 | |||||
タイトル | ||||||
タイトル | Muscle-specific tyrosine kinase-antibody-positive myasthenic crisis with detailed electrophysiologic studies. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MuSK-antibody-positive myasthenia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | respiratory arrest | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | edrophonium test | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | electrophysiological study | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yanagawa, Youichi
× Yanagawa, Youichi× Hongo, Yu× Shiozaki, Hiroshi× Kamakura, Keiko× Sonoo, Masahiro× Motomura, Masakatsu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A 69-year-old male who presented in a coma due to sudden respiratory arrest was transferred to our hospital. After endotracheal intubation with manual ventilation, he became alert and his neurologic findings were within the normal range, except for palsy of the respiratory muscles. Biochemical analyses of the blood and brain computed tomography failed to indicate the cause of the respiratory arrest. An edrophonium test did not improve the respiratory arrest. An urgent electromyogram at the dorsal interossei, biceps, and sternocleidomastoideus muscle and a repetitive nerve stimulation test at the trapezius and deltoid muscle were also negative on the first hospital day. However, on the 16th day in the hospital, a repetitive nerve stimulation test at the levator labii superioris alaeque nasi showed a waning phenomenon. This result indicated a diagnosis of myasthenia gravis. Anti.muscle-specific tyrosine kinase antibody was found to be positive. After treatment with plasmapheresis and prednisolone, he regained normal respiratory function. Anti.muscle-specific tyrosine kinase (MuSK)-antibodypositive myasthenia gravis (MG) (MuSK-MG) tends to be associated with a lower incidence of a positive edrophonium test, a lower incidence of a positive electrophysiologic study excluding the face, and a higher incidence of respiratory failure in comparison to anti.acetylcholine receptors (AchR)-antibody-positive MG (AchR-MG). Respiratory failure is curable with treatment. Accordingly, in addition to obtaining a precise diagnosis, an emergency physician should recommend an electrophysiologic study including the face to make a differential diagnosis for respiratory arrest when biochemical and radiologic studies fail to indicate the cause of the respiratory arrest. | |||||
書誌情報 |
The American journal of emergency medicine 巻 27, 号 6, p. 754.e5-754.e6, 発行日 2009-07 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 07356757 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1532-8171 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10642870 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19751644 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ajem.2008.10.005 | |||||
権利 | ||||||
権利情報 | Copyright © 2009 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The American journal of emergency medicine, 27(6), pp.754.e5-754.e6; 2009 |