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Pitavastatin Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells.
http://hdl.handle.net/10069/23013
http://hdl.handle.net/10069/23013c2a72f94-3efe-4bfe-bdd2-94d07abca5ce
名前 / ファイル | ライセンス | アクション |
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CMN30_727.pdf (688.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-25 | |||||
タイトル | ||||||
タイトル | Pitavastatin Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blood-brain barrier | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brain endothelial cells (rat) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Claudin-5 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Geranyl geranylation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pitavastatin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Statins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tight junctions | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transendothelial electrical resistance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Morofuji, Yoichi
× Morofuji, Yoichi× Nakagawa, Shinsuke× So, Gohei× Hiu, Takeshi× Horai, Shoji× Hayashi, Kentaro× Tanaka, Kunihiko× Suyama, Kazuhiko× Deli, Maria A× Nagata, Izumi× Niwa, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Statins have a neuroprotective effect in neurological diseases, a pleiotropic effect possibly related to blood-brain barrier (BBB) function. We investigated the effect of pitavastatin on barrier functions of an in vitro BBB model with primary cultures of rat brain capillary endothelial cells (RBEC). Pitavastatin increased the transendothelial electrical resistance (TEER), an index of barrier tightness of interendothelial tight junctions (TJs), at a concentration of 10(-8) M, and decreased the endothelial permeability for sodium fluorescein through the RBEC monolayer. The increase in TEER was significantly reduced in the presence of isoprenoid geranylgeranyl pyrophosphate, whereas farnesyl pyrophosphate had no effect on TEER. Our immunocytochemical and Western blot analyses revealed that treatment with pitavastatin enhanced the expression of claudin-5, a main functional protein of TJs. Our data indicate that pitavastatin strengthens the barrier integrity in primary cultures of RBEC. The BBB-stabilizing effect of pitavastatin may be mediated partly through inhibition of the mevalonate pathway and subsequent up-regulation of claudin-5 expression. | |||||
書誌情報 |
Cellular and molecular neurobiology 巻 30, 号 5, p. 727-735, 発行日 2010-07 |
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出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02724340 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15736830 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10622352 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20127168 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10571-010-9497-9 | |||||
権利 | ||||||
権利情報 | © Springer Science+Business Media, LLC 2010 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cellular and molecular neurobiology, 30(5), pp.727-735; 2010 |