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Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells.
http://hdl.handle.net/10069/23017
http://hdl.handle.net/10069/23017414b5719-4586-4835-86e1-f9fd593a875b
名前 / ファイル | ライセンス | アクション |
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Bio28_3469.pdf (715.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemotaxis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fibronectin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Histomorphometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Implant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osseointegration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Jimbo, Ryo
× Jimbo, Ryo× Sawase, Takashi× Shibata, Yasuaki× Hirata, Kazunari× Hishikawa, Yoshitaka× Tanaka, Yasuhiro× Bessho, Kazuhisa× Ikeda, Tohru× Atsuta, Mitsuru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Plasma fibronectin (pFN) is known to regulate cell growth, differentiation or survival of osteoblasts in vitro. It is also speculated to be important for the early phase of osseointegration, however, its actual in vivo behavior is unknown. The objective of this study is to clarify the role of pFN during osseointegration. We developed a titanium ion-plated acrylic implant (Ti-acryl) for thin sectioning without removal of the implant. Either Ti-acryl or pFN-coated Ti-acryl (FN-Ti-acryl) was implanted in the mouse femur. Samples were taken on days 1-7 and on day 14 after the operation, and were decalcified and paraffin embedded. The bone healing process and immunofluorescence localization of pFN and cellular fibronectin (cFN), a marker for fibroblastic cells were examined. Simultaneously, the effect of pFN on chemotaxis, proliferation and differentiation of bone marrow stromal cells (BMSCs) was analyzed in vitro. The in vivo results showed that faster direct bone formation was seen for the FN-Ti-acryl group compared to the Ti-acryl group. The in vitro results showed that pFN significantly promoted BMSCs chemotaxis, however, had no effect on proliferation or differentiation. The results indicate that pFN regulated chemotaxis of osteogenic cells and coating the implant with pFN enhanced earlier osseointegration. | |||||
書誌情報 |
Biomaterials 巻 28, 号 24, p. 3469-3477, 発行日 2007-08 |
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出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01429612 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | AA11522637 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 17512051 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.biomaterials.2007.04.029 | |||||
権利 | ||||||
権利情報 | Copyright © 2007 Elsevier Ltd All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biomaterials, 28(24), pp.3469-3477; 2007 |