WEKO3
アイテム
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The antiviral protein cyanovirin-N: the current state of its production and applications.
http://hdl.handle.net/10069/25148
http://hdl.handle.net/10069/251481bd5cfec-1d13-45c7-a8a7-82152fb79756
名前 / ファイル | ライセンス | アクション |
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AMB86_805.pdf (333.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-05-25 | |||||
タイトル | ||||||
タイトル | The antiviral protein cyanovirin-N: the current state of its production and applications. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cyanovirin-N | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gp120 binding | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Heterologous production | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human immunodeficiency virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microbicide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pharmacological evaluation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Xiong, Sheng
× Xiong, Sheng× Fan, Jun× Kitazato, Kaio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Human immunodeficiency virus (HIV)/AIDS continues to spread worldwide, and most of the HIV-infected people living in developing countries have little or no access to highly active antiretroviral therapy. The development of efficient and low-cost microbicides to prevent sexual transmission of HIV should be given high priority because there is no vaccine available yet. Cyanovirin-N (CVN) is an entry inhibitor of HIV and many other viruses, and it represents a new generation of microbicide that has specific and potent activity, a different mechanism of action, and unusual chemicophysical stability. In vitro and in vivo antiviral tests suggested that the anti-HIV effect of CVN is stronger than a well-known gp120-targeted antibody (2G12) and another microbicide candidate, PRO2000. CVN is a cyanobacteria-derived protein that has special structural features, making the artificial production of this protein very difficult. In order to develop an efficient and relatively low-cost approach for large-scale production of recombinant CVN to satisfy medical use, this protein has been expressed in many systems by trial and error. Here, to summarize the potential and remaining challenges for the development of this protein into an HIV prevention agent, the progress in the structural mechanism determination, heterologous production and pharmacological evaluation of CVN is reviewed. | |||||
書誌情報 |
Applied microbiology and biotechnology 巻 86, 号 3, p. 805-812, 発行日 2010-04 |
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出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01757598 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14320614 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10503386 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20162270 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00253-010-2470-1 | |||||
権利 | ||||||
権利情報 | © Springer-Verlag 2010 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Applied microbiology and biotechnology, 86(3), pp.805-812; 2010 |