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Regeneration of the mesothelium has been reported in the normal peritoneum but not the fibrotic peritoneum. Moreover, the origin of the regenerated mesothelial cells remains obscure. The aim of this study was to investigate mesothelial regeneration in fibrotic peritoneum induced by chlorhexidine gluconate. Methods. Peritoneal fibrosis was induced by injection of CG into the peritoneal cavity of Wistar rats. After injection, the abdomen was opened, and the parietal fibrotic peritoneum with mesothelial cells was stripped from the abdominal wall, and then the abdominal incision was closed. Rats were sacrificed, and peritoneal tissues were dissected out at 0, 1, 3, 5, or 7 days after the stripping procedure. Results. Spindle-shaped cells with microvilli appeared on the surface of stripped peritoneum at day 3 after denudation. Immunohistochemistry identified staining for vimentin, a marker of mesoderm cells, in the spindle-shaped cells at days 3, 5, and 7. 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Regeneration of Peritoneal Mesothelium in a Rat Model of Peritoneal Fibrosis
http://hdl.handle.net/10069/23163
http://hdl.handle.net/10069/23163fb780aef-9af6-45a5-8ee6-4cdadd8ebb3a
名前 / ファイル | ライセンス | アクション |
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RenFai30_97.pdf (566.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-20 | |||||
タイトル | ||||||
タイトル | Regeneration of Peritoneal Mesothelium in a Rat Model of Peritoneal Fibrosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mesenchymal cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mesenchymal-epithelial transition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mesothelial cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Regeneration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishioka, Yoshiaki
× Nishioka, Yoshiaki× Miyazaki, Masanobu× Abe, Katsushige× Furusu, Akira× Harada, Takashi× Ozono, Yoshiyuki× Taguchi, Takashi× Koji, Takehiko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Patients on long-term peritoneal dialysis develop progressive peritoneal fibrosis and loss of mesothelial layer. Regeneration of the mesothelium has been reported in the normal peritoneum but not the fibrotic peritoneum. Moreover, the origin of the regenerated mesothelial cells remains obscure. The aim of this study was to investigate mesothelial regeneration in fibrotic peritoneum induced by chlorhexidine gluconate. Methods. Peritoneal fibrosis was induced by injection of CG into the peritoneal cavity of Wistar rats. After injection, the abdomen was opened, and the parietal fibrotic peritoneum with mesothelial cells was stripped from the abdominal wall, and then the abdominal incision was closed. Rats were sacrificed, and peritoneal tissues were dissected out at 0, 1, 3, 5, or 7 days after the stripping procedure. Results. Spindle-shaped cells with microvilli appeared on the surface of stripped peritoneum at day 3 after denudation. Immunohistochemistry identified staining for vimentin, a marker of mesoderm cells, in the spindle-shaped cells at days 3, 5, and 7. Expression of α-SMA was observed in the same cells at days 3 and 5, but not 7. Expression of cytokeratin and HBME-1, markers for mesothelial cells, in these cells was delayed until day 7. Conclusions. Mesothelium can regenerate on the fibrotic peritoneum. The regenerated mesothelial cells seem to originate from vimentin-positive mesenchymal cells. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This is an electronic version of an article published in Renal Failure, 30(1), pp.97-105; 2008. Renal Failure is available online at: http://www.informaworld.com/openurl?genre=article&id=doi:10.1080/08860220701741619. | |||||
書誌情報 |
Renal Failure 巻 30, 号 1, p. 97-105, 発行日 2008-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0886022X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15256049 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10710347 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/08860220701741619 | |||||
権利 | ||||||
権利情報 | Copyright © Informa Healthcare USA, Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Renal Failure, 30(1), pp.97-105; 2008 |