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Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: a comparative study on ascophyllan and fucoidan.
http://hdl.handle.net/10069/23300
http://hdl.handle.net/10069/2330088589c8e-319f-4d05-b5d5-1371e1b1cbc2
名前 / ファイル | ライセンス | アクション |
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JBB110_113.pdf (991.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-07-07 | |||||
タイトル | ||||||
タイトル | Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: a comparative study on ascophyllan and fucoidan. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ascophyllan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ascophyllum nodosum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytotoxicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fucoidan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Growth promotion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MDCK cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sulfated fucan | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Jiang, Zedong
× Jiang, Zedong× Okimura, Takasi× Yokose, Takeshi× Yamasaki, Yasuhiro× Yamaguchi, Kenichi× Oda, Tatsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effects of fucose-containing sulfated polysaccharides, ascophyllan and fucoidan, isolated from the brown alga Ascophyllum nodosum, on the growth of various cell lines (MDCK, Vero, PtK(1), CHO, HeLa, and XC) were investigated. In a colony formation assay, ascophyllan and fucoidan showed potent cytotoxic effects on Vero and XC cells, while other cell lines were relatively resistant to these polysaccharides. Almost no significant effects of these polysaccharides were observed in the cell lines tested using the Alamar blue cytotoxicity assay over 48 h with varying initial cell densities (2500-20,000 cells/well) in growth medium. Interestingly, a significant growth promoting effect of ascophyllan on MDCK cells was observed, whereas treatment with fucoidan showed growth suppressive effects on this cell line under the same experimental conditions. These results suggest that ascophyllan is distinguishable from fucoidan in terms of their bioactivities. This is the first report of the growth promoting effects of a sulfated fucan on a mammalian cell line under normal growth conditions. | |||||
書誌情報 |
Journal of bioscience and bioengineering 巻 110, 号 1, p. 113-117, 発行日 2010-07 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13891723 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13474421 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11307678 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20541128 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jbiosc.2010.01.007 | |||||
権利 | ||||||
権利情報 | Copyright © 2010 The Society for Biotechnology, Japan Published by Elsevier B.V. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of bioscience and bioengineering, 110(1), pp.113-117; 2010 |