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Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration: a Comparative Study with Morphine.
http://hdl.handle.net/10069/38838
http://hdl.handle.net/10069/388382d5e5bce-89ff-4f8a-93c3-563945f0ac98
名前 / ファイル | ライセンス | アクション |
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BPB19_477.pdf (563.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-21 | |||||
タイトル | ||||||
タイトル | Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration: a Comparative Study with Morphine. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dihydroetorphine (DHE) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | morphine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antinociception | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TOKUYAMA, Shogo
× TOKUYAMA, Shogo× NAKAMURA, Fumihiro× TAKAHASHI, Masakatsu× KANETO, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Using various routes of administration, the antinociceptive effects of dihydroetorphine (DHE) and morphine were measured in mice. Regardless of the route of systemic and local administration, DHE (1-20μg/kg, i.p. ; 1-10μg/kg, s.c. ; 1-10μg/kg, i.v. ; 10-1000μg/kg, p.o. ; 10-100ng/mouse, intracerebroventricularly (i.c.v.) ; and 10-100ng/mouse, intrathecally (i.t.)) and morphine (1-20mg/kg, i.p. ; 1-10mg/kg, s.c. ; 1-10mg/kg, i.v. ; 10-100mg/kg, p.o. ; 1-10μg/mouse, i.c.v. ; and 0.5-3μg/mouse, i.t.) produced an antinociceptive effect in a dose-dependent manner, as evaluated by the tail pinch method. However, the duration of the antinociceptive effect of DHE was shorter than that of morphine. The efficacy ratio of the antinociceptive effect between DHE and morphine was approximately 1000 to 1500 : 1 by parenteral administration (i.p., s.c., or i.v.) and about 100 : 1 by the oral route. Meanwhile, using direct application into the central nervous system (CNS) (i.c.v. or i.t.), the effect of DHE was only 10 to 20 times that of morphine. These data suggest that DHE has an ideal quality as an analgesic by systemic administration which is a more convenient application than local injection, since only a minimum dose of DHE is needed to induce suitable potency of antinociception, and the duration of the effect is short. Further, these unique characteristics of DHE might lead to the prevention of the development of dependence by avoiding accumulation of the drug in the CNS. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 19, 号 3, p. 477-479, 発行日 1996-03-15 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.19.477 | |||||
権利 | ||||||
権利情報 | c The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 19(3), pp.477-479; 1996 |