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Further Evidence for the Participation of an α2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice.
http://hdl.handle.net/10069/38852
http://hdl.handle.net/10069/388529b8cd7a3-21af-4a88-8ecb-f4cb31bcd91f
名前 / ファイル | ライセンス | アクション |
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JPD14_637.pdf (523.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-21 | |||||
タイトル | ||||||
タイトル | Further Evidence for the Participation of an α2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α2-adrenoceptor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TOKUYAMA, Shogo
× TOKUYAMA, Shogo× TAKAHASHI, Masakatsu× KANETO, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Subanalgesic dose, 0.01 to 0.25 mg/kg, of clonidine (CLO), an α2-adrenoceptor agonist, potentiated forced swimming (SW) stress induced analgesia (SIA) and suppressed psychological (PSY)-SIA in a dose dependent manner but did not affect foot-shock (FS)-SIA. Daily exposure to each stress rapidly developed tolerance, and the development was suppressed by daily concomitant subanalgesic dose of CLO in SW-SIA but not in FS- and PSY-SIA. Meanwhile, SW-stress, applied after injection of CLO, 1 mg/kg, potentiated the analgesic effect of CLO and suppressed the development of tolerance to the effect. On the other hand, FS- and PSY-stress did not affect CLO analgesia and failed to block the tolerance development. These results provide further evidence that α2-adrenergic mechanism is involved in the production of SW-SIA. | |||||
書誌情報 |
Journal of Pharmacobio-Dynamics 巻 14, 号 11, p. 637-641, 発行日 1991 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0386846X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18811353 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00704585 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb1978.14.637 | |||||
権利 | ||||||
権利情報 | c The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmacobio-Dynamics, 14(11), pp.637-641; 1991 |