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Oxidative stress and tumor progression in colorectal cancer
http://hdl.handle.net/10069/23101
http://hdl.handle.net/10069/23101ae0f76e7-0153-4a54-9a40-b5b27b80a498
名前 / ファイル | ライセンス | アクション |
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HG56_343.pdf (169.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-04-05 | |||||
タイトル | ||||||
タイトル | Oxidative stress and tumor progression in colorectal cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | colorectal cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Denvative-reactive oxygen metabolites (d-ROM) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reactive oxygen species (ROS) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thymidine phosphorylase | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Inokuma, Takamitsu
× Inokuma, Takamitsu× Haraguchi, Masashi× Fujita, Fumihiko× Tajima, Yoshitsugu× Kanematsu, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background / Aims: Elevated oxidative status has been found in many types of cancer cells. Recent studies have shown that the enzymatic product of thymidine phosphorylase (TP) generated reactive oxygen species (ROS) within cancer cells. The aim of this study was thus to evaluate the signal transduction pathway and the role of ROS in colorectal cancer. Methodology: Blood specimens were obtained from the drainage vein of the tumor during operation in 76 patients with colorectal cancer. Serum ROS levels were measured using the derivative-Reactive Oxygen Metabolites (d-ROM) test and serum TP levels were examined by a highly sensitive ELISA method. Results: There was no significant correlation between serum levels of ROS and TP. Serum ROS levels were elevated in proportion to tumor invasion and had a significant positive correlation with tumor size (p<0.05). However, they did not increase in patients with liver metastasis. Conclusions: These findings suggest that ROS are independent of TP-triggered signaling transduction and are associated with increased tumor invasion, but not liver metastasis in patients with colorectal cancer. From this point of view, new strategies related to ROS may provide improved therapeutic results as well as a preventative effect on carcinogenesis of the colorectum. | |||||
書誌情報 |
Hepato-Gastroenterology 巻 56, 号 90, p. 343-347, 発行日 2009-03 |
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出版者 | ||||||
出版者 | Thieme | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01726390 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00213244 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19579595 | |||||
権利 | ||||||
権利情報 | c H.G.E. Update Medical Publishing S.A. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://www.iasg.org/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hepato-Gastroenterology, 56(90), pp.343-347; 2009 |