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Effect of dietary fatty acid composition on Th1/Th2 polarization in lymphocytes.
http://hdl.handle.net/10069/23352
http://hdl.handle.net/10069/23352d3f46ffd-91e4-4f3f-849c-29e9da0437ae
名前 / ファイル | ライセンス | アクション |
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JPEN33_390.pdf (336.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-02 | |||||
タイトル | ||||||
タイトル | Effect of dietary fatty acid composition on Th1/Th2 polarization in lymphocytes. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α-linolenic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enteral nutrition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polyunsaturated fatty acids | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T lymphocyte | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mizota, Takamitsu
× Mizota, Takamitsu× Fujita-Kambara, Chiaki× Matsuya, Nemu× Hamasaki, Shinji× Fukudome, Takayasu× Goto, Hirofumi× Nakane, Shunya× Kondo, Takayuki× Matsuo, Hidenori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: It has become increasingly clear that polyunsaturated fatty acids (PUFAs) have immunomodulatory effects. However, the intake of these fatty acids used in animal studies often greatly exceeds dietary human intake. Whether differences in the composition of fatty acids that are consumed in amounts consistent with normal dietary intake can influence immune function remains uncertain. METHODS: We manufactured 3 types of liquid diet, related to modified fatty acid composition (omega-6/omega-3 = 0.25, 2.27 and 42.9), but excluding eicosapentaenoic acid and docosahexaenoic acid, based upon a liquid diet used clinically in humans. We assessed CD3-stimulated cytokine production of splenocytes in female BALB/c mice (n = 4 per group) fed 1 of 3 liquid diets for 4 weeks. We also measured the cytokine production of peripheral blood mononuclear cells stimulated with phorbol myristate acetate and ionomycin in humans at the end of a 4-week period of consumption of 2 different liquid diets (omega-6/omega-3 = 3 and 44). RESULTS: We found that the ratio of interfero omega-gamma (IFN-gamma) / interleukin-4 (IL-4) was significantly higher in mice fed the omega-3 rich diet than in others. In humans, IFN-gamma / IL-4 was significantly higher after the omega-3 versus the omega-6 enhanced diet. CONCLUSIONS: Differences in the composition of omega-3 and omega-6 PUFAs induces a shift in the Th1/Th2 balance in both mouse and human lymphocytes, even when ingested in normal dietary amounts. An omega-3 rich diet containing alpha-linolenic acid modulates immune function. | |||||
書誌情報 |
JPEN. Journal of parenteral and enteral nutrition 巻 33, 号 4, p. 390-396, 発行日 2009-07 |
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出版者 | ||||||
出版者 | SAGE | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01486071 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00258945 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19221048 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1177/0148607108325252 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JPEN. Journal of parenteral and enteral nutrition, 33(4), pp.390-396; 2009 |