WEKO3
アイテム
{"_buckets": {"deposit": "cbad37ff-9b1e-486d-a201-f2112d561692"}, "_deposit": {"created_by": 2, "id": "16383", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16383"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016383", "sets": ["9"]}, "author_link": ["62038", "62042", "62032", "62036", "62035", "62030", "62039", "62034", "62033", "62040", "62037", "62031", "62041"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "2302", "bibliographicPageStart": "2299", "bibliographicVolumeNumber": "51", "bibliographic_titles": [{"bibliographic_title": "Diabetologia"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "AIMS/HYPOTHESIS: We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein. METHODS: Autoantibodies to ZnT8 were determined by RIA in 270 patients with type 1 diabetes using ZnT8 carboxy-terminal constructs (amino acids 268-369) carrying 325Trp(CW) and 325Arg(CR) and a hybrid construct (CW-CR). Forty-four ZnT8 autoantibody-positive sera with genomic DNA were used to examine the association between reactivity to ZnT8 constructs and the rs13266634 genotype. RESULTS: Seventy-five patients reacted to the CW-CR hybrid construct, whereas 37 and 36 patients reacted to the CW and CR constructs, respectively. All sera positive for either CW or CR autoantibodies were positive for CW-CR autoantibodies. Among 19 patients with a 325Arg(CC) genotype, 5% had CW-specific autoantibodies, 42% had CR-specific autoantibodies and 32% had dual reactivity. Conversely, 73% of 15 patients with the 325Trp(TT) genotype had CW-specific autoantibodies, no patients had CR-specific autoantibodies and 13% had dual reactivity. Nine of the ten patients (90%) with the CT genotype reacted with either CR or CW constructs. The titre of CR autoantibodies in patients carrying the C allele was significantly higher than that in TT homozygotes (p \u003c 0.0001). In contrast, the titre of CW autoantibodies in patients carrying a T allele was significantly higher than that in CC homozygotes (p \u003c 0.005). No evidence of an association between rs13266634 and type 1 diabetes was observed. CONCLUSIONS/INTERPRETATION: These results indicate that variant residue at amino acid 325 is a key determinant of humoral autoreactivity to ZnT8 and that the SLC30A8 genotype is an important determinant of autoantibody specificity.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Diabetologia, 51(12), pp.2299-2302; 2009", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Berlin"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "18850084", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s00125-008-1165-y", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c Springer-Verlag 2008"}, {"subitem_rights": "The original publication is available at www.springerlink.com"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00628104", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0012186X", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1432-0428", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawasaki, Eiji"}], "nameIdentifiers": [{"nameIdentifier": "62030", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uga, Mho"}], "nameIdentifiers": [{"nameIdentifier": "62031", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Kazuhiko T."}], "nameIdentifiers": [{"nameIdentifier": "62032", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuriya, Genpei"}], "nameIdentifiers": [{"nameIdentifier": "62033", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Satoh, T"}], "nameIdentifiers": [{"nameIdentifier": "62034", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujishima, Keiichiro"}], "nameIdentifiers": [{"nameIdentifier": "62035", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozaki, M"}], "nameIdentifiers": [{"nameIdentifier": "62036", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abiru, Norio"}], "nameIdentifiers": [{"nameIdentifier": "62037", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki, H"}], "nameIdentifiers": [{"nameIdentifier": "62038", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wenzlau, Janet M."}], "nameIdentifiers": [{"nameIdentifier": "62039", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Davidson, Howard W."}], "nameIdentifiers": [{"nameIdentifier": "62040", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hutton, J C"}], "nameIdentifiers": [{"nameIdentifier": "62041", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi, K"}], "nameIdentifiers": [{"nameIdentifier": "62042", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Diabetologia51_2299.pdf", "filesize": [{"value": "124.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 124800.0, "url": {"label": "Diabetologia51_2299.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16383/files/Diabetologia51_2299.pdf"}, "version_id": "80ab08d1-6a91-42fb-bcec-f3659852f9d3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Autoantibodies", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Epitope", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Genetics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Japanese population", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SLC30A8", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Type 1 diabetes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Zinc transporter-8", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes."}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/22262", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-10-20"}, "publish_date": "2009-10-20", "publish_status": "0", "recid": "16383", "relation": {}, "relation_version_is_last": true, "title": ["Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes."], "weko_shared_id": 2}
Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.
http://hdl.handle.net/10069/22262
http://hdl.handle.net/10069/22262d77e649b-b984-403c-94e1-094b77eb5a22
名前 / ファイル | ライセンス | アクション |
---|---|---|
Diabetologia51_2299.pdf (124.8 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-10-20 | |||||
タイトル | ||||||
タイトル | Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoantibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epitope | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japanese population | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SLC30A8 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type 1 diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Zinc transporter-8 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawasaki, Eiji
× Kawasaki, Eiji× Uga, Mho× Nakamura, Kazuhiko T.× Kuriya, Genpei× Satoh, T× Fujishima, Keiichiro× Ozaki, M× Abiru, Norio× Yamasaki, H× Wenzlau, Janet M.× Davidson, Howard W.× Hutton, J C× Eguchi, K |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | AIMS/HYPOTHESIS: We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein. METHODS: Autoantibodies to ZnT8 were determined by RIA in 270 patients with type 1 diabetes using ZnT8 carboxy-terminal constructs (amino acids 268-369) carrying 325Trp(CW) and 325Arg(CR) and a hybrid construct (CW-CR). Forty-four ZnT8 autoantibody-positive sera with genomic DNA were used to examine the association between reactivity to ZnT8 constructs and the rs13266634 genotype. RESULTS: Seventy-five patients reacted to the CW-CR hybrid construct, whereas 37 and 36 patients reacted to the CW and CR constructs, respectively. All sera positive for either CW or CR autoantibodies were positive for CW-CR autoantibodies. Among 19 patients with a 325Arg(CC) genotype, 5% had CW-specific autoantibodies, 42% had CR-specific autoantibodies and 32% had dual reactivity. Conversely, 73% of 15 patients with the 325Trp(TT) genotype had CW-specific autoantibodies, no patients had CR-specific autoantibodies and 13% had dual reactivity. Nine of the ten patients (90%) with the CT genotype reacted with either CR or CW constructs. The titre of CR autoantibodies in patients carrying the C allele was significantly higher than that in TT homozygotes (p < 0.0001). In contrast, the titre of CW autoantibodies in patients carrying a T allele was significantly higher than that in CC homozygotes (p < 0.005). No evidence of an association between rs13266634 and type 1 diabetes was observed. CONCLUSIONS/INTERPRETATION: These results indicate that variant residue at amino acid 325 is a key determinant of humoral autoreactivity to ZnT8 and that the SLC30A8 genotype is an important determinant of autoantibody specificity. | |||||
書誌情報 |
Diabetologia 巻 51, 号 12, p. 2299-2302, 発行日 2008-12 |
|||||
出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0012186X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1432-0428 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00628104 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18850084 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00125-008-1165-y | |||||
権利 | ||||||
権利情報 | c Springer-Verlag 2008 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Diabetologia, 51(12), pp.2299-2302; 2009 |