WEKO3
アイテム
{"_buckets": {"deposit": "1df1a556-ec87-44ad-b86f-a2db4eadde18"}, "_deposit": {"created_by": 2, "id": "16409", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16409"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016409", "sets": ["11"]}, "author_link": ["62181", "62179", "62177", "62182", "62180", "62176", "62178"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "1875", "bibliographicPageStart": "1869", "bibliographicVolumeNumber": "53", "bibliographic_titles": [{"bibliographic_title": "Digestive diseases and sciences"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "PURPOSE: To determine whether simvastatin is able to inhibit inflammation in trinitrobenzene sulfonic acid (TNBS)-induced or oxazalone (OXA)-induced colitis. RESULTS: In the prophylactic protocol, simvastatin dose-dependently suppressed the decrease in body weight and inflammatory grade of TNBS-treated mice. In contrast, in the therapeutic protocol, no significant difference in body weight reduction was observed between simvastatin-treated and control mice. IFN-gamma release from LP cells was significantly suppressed in mice receiving high-dose simvastatin in the prophylactic protocol. In contrast to TNBS colitis, even high-dose prophylactic simvastatin had no suppressive effects on either weight reduction or the inflammatory grade in OXA colitis. CONCLUSION: Our results indicate that simvastatin negatively regulates inflammation in TNBS-induced colitis, but not in OXA-induced colitis. In TNBS-induced colitis, simvastatin suppressed the Th1-polarized immune response. Our findings suggest that simvastatin has potential effects as a therapeutic agent in human inflammatory bowel disease, particularly Crohn\u0027s disease.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Digestive diseases and sciences, 53(7), pp.1869-1875; 2008", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Netherlands"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "18049901", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s10620-007-0102-0", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c Springer Science+Business Media, LLC 2007"}, {"subitem_rights": "The original publication is available at www.springerlink.com"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00161107", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "01632116", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1573-2568", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ikeda, Maho"}], "nameIdentifiers": [{"nameIdentifier": "62176", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeshima, Fuminao"}], "nameIdentifiers": [{"nameIdentifier": "62177", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Isomoto, Hajime"}], "nameIdentifiers": [{"nameIdentifier": "62178", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shikuwa, Saburo"}], "nameIdentifiers": [{"nameIdentifier": "62179", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuta, Yohei"}], "nameIdentifiers": [{"nameIdentifier": "62180", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozono, Yoshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "62181", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohno, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "62182", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DDS53_1869.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "DDS53_1869.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16409/files/DDS53_1869.pdf"}, "version_id": "fcfe8ac8-000b-4a7b-ae6c-cbfc8a7049f0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Colitis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Simvastatin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Statin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNBS", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis."}]}, "item_type_id": "2", "owner": "2", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/22287", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-10-23"}, "publish_date": "2009-10-23", "publish_status": "0", "recid": "16409", "relation": {}, "relation_version_is_last": true, "title": ["Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis."], "weko_shared_id": -1}
Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis.
http://hdl.handle.net/10069/22287
http://hdl.handle.net/10069/2228703c2d7c9-924e-4930-98fb-5ede557d298c
名前 / ファイル | ライセンス | アクション |
---|---|---|
DDS53_1869.pdf (1.7 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-10-23 | |||||
タイトル | ||||||
タイトル | Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Colitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Simvastatin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Statin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNBS | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ikeda, Maho
× Ikeda, Maho× Takeshima, Fuminao× Isomoto, Hajime× Shikuwa, Saburo× Mizuta, Yohei× Ozono, Yoshiyuki× Kohno, Shigeru |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: To determine whether simvastatin is able to inhibit inflammation in trinitrobenzene sulfonic acid (TNBS)-induced or oxazalone (OXA)-induced colitis. RESULTS: In the prophylactic protocol, simvastatin dose-dependently suppressed the decrease in body weight and inflammatory grade of TNBS-treated mice. In contrast, in the therapeutic protocol, no significant difference in body weight reduction was observed between simvastatin-treated and control mice. IFN-gamma release from LP cells was significantly suppressed in mice receiving high-dose simvastatin in the prophylactic protocol. In contrast to TNBS colitis, even high-dose prophylactic simvastatin had no suppressive effects on either weight reduction or the inflammatory grade in OXA colitis. CONCLUSION: Our results indicate that simvastatin negatively regulates inflammation in TNBS-induced colitis, but not in OXA-induced colitis. In TNBS-induced colitis, simvastatin suppressed the Th1-polarized immune response. Our findings suggest that simvastatin has potential effects as a therapeutic agent in human inflammatory bowel disease, particularly Crohn's disease. | |||||
書誌情報 |
Digestive diseases and sciences 巻 53, 号 7, p. 1869-1875, 発行日 2008-07 |
|||||
出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01632116 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1573-2568 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00161107 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18049901 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10620-007-0102-0 | |||||
権利 | ||||||
権利情報 | c Springer Science+Business Media, LLC 2007 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Digestive diseases and sciences, 53(7), pp.1869-1875; 2008 |