WEKO3
アイテム
{"_buckets": {"deposit": "3ee170ee-6853-4a6a-abca-ffd2efc4109b"}, "_deposit": {"created_by": 2, "id": "16460", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16460"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016460", "sets": ["30"]}, "author_link": ["62511", "62518", "62509", "62508", "62516", "62515", "62521", "62514", "62517", "62510", "62513", "62520", "62512", "62519"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "703", "bibliographicPageStart": "697", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "International Journal of Oncology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Adult T-cell leukemia/lymphoma (ATLL) is a neoplasia characterized by the massive invasion of various organs by tumor cells. Previously, we found that expression of the gene for c-Met, a receptor tyrosine kinase for hepatocyte growth factor (HGF), was specific to the acute type among 41 patients with ATLL by microarray. First in the present study, we analyzed the survival of the patients in relation to expression of c-Met and HGF in ATLL cells. Expression of the former but not the latter was associated with poor prognosis. Then, we analyzed the growth of ATLL cells caused by HGF and c-Met. c-Met was expressed in 0/7 chronic ATLLs, 12/14 acute ATLLs, 1/1 IL-2-independent ATLL cell line and 1/7 IL-2-dependent ATLL cell lines as assessed by flow cytometry. HGF induced the proliferation of primary cells from most acute cases examined as well as the c-Met-positive KK1 cell line in contrast to c-Met-negative cells. HGF induced autophosphorylation of c-Met in c-Met-positive cells from an acute case and KK1 cells. The plasma level of HGF was elevated in acute as compared to chronic cases. The levels of HGF and/or IL-6 which induces the production of HGF by stromal cells, were elevated in the supernatant of short-term cultured cells from certain patients with acute or chronic disease. Finally, infiltrated ATLL cells and adjacent stromal cells in liver were shown to be positive for c-Met/HGF and HGF, respectively, in acute cases. Autocrine and/or paracrine growth caused by HGF and c-Met was suggested in aggressive ATLL cells secreting HGF and/or IL-6, respectively.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "International Journal of Oncology, 33(4), pp.697-703; 2008", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Spandidos Publications"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "18813782", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3892/ijo_00000055", "subitem_relation_type_select": "DOI"}}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10992511", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "10196439", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "17912423", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Onimaru, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "62508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsukasaki, Kunihiro"}], "nameIdentifiers": [{"nameIdentifier": "62509", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, K"}], "nameIdentifiers": [{"nameIdentifier": "62510", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imaizumi, Yoshitaka"}], "nameIdentifiers": [{"nameIdentifier": "62511", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Choi, Y.L"}], "nameIdentifiers": [{"nameIdentifier": "62512", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasegawa, H"}], "nameIdentifiers": [{"nameIdentifier": "62513", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugahara, K"}], "nameIdentifiers": [{"nameIdentifier": "62514", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Yasuo M A"}], "nameIdentifiers": [{"nameIdentifier": "62515", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, T"}], "nameIdentifiers": [{"nameIdentifier": "62516", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, M"}], "nameIdentifiers": [{"nameIdentifier": "62517", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taguchi, T"}], "nameIdentifiers": [{"nameIdentifier": "62518", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mano, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "62519", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamihira, Shimeru"}], "nameIdentifiers": [{"nameIdentifier": "62520", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomonaga, M"}], "nameIdentifiers": [{"nameIdentifier": "62521", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "IJO33_697.pdf", "filesize": [{"value": "266.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 266100.0, "url": {"label": "IJO33_697.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16460/files/IJO33_697.pdf"}, "version_id": "4209768d-1c0d-42d4-9d52-1cc29d859051"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "adult T-cell leukemia/lymphoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human T-lymphotropic virus type-I", "subitem_subject_scheme": "Other"}, {"subitem_subject": "c-Met", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hepatocyte growth factor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "autocrine/paracrine", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/22340", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-11-09"}, "publish_date": "2009-11-09", "publish_status": "0", "recid": "16460", "relation": {}, "relation_version_is_last": true, "title": ["Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met"], "weko_shared_id": -1}
Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met
http://hdl.handle.net/10069/22340
http://hdl.handle.net/10069/22340744a5e91-6c07-4d5f-9ad1-78467fad2dee
名前 / ファイル | ライセンス | アクション |
---|---|---|
IJO33_697.pdf (266.1 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-11-09 | |||||
タイトル | ||||||
タイトル | Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adult T-cell leukemia/lymphoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human T-lymphotropic virus type-I | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | c-Met | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatocyte growth factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autocrine/paracrine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Onimaru, Yasuyuki
× Onimaru, Yasuyuki× Tsukasaki, Kunihiro× Murata, K× Imaizumi, Yoshitaka× Choi, Y.L× Hasegawa, H× Sugahara, K× Yamada, Yasuo M A× Hayashi, T× Nakashima, M× Taguchi, T× Mano, Hiroyuki× Kamihira, Shimeru× Tomonaga, M |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adult T-cell leukemia/lymphoma (ATLL) is a neoplasia characterized by the massive invasion of various organs by tumor cells. Previously, we found that expression of the gene for c-Met, a receptor tyrosine kinase for hepatocyte growth factor (HGF), was specific to the acute type among 41 patients with ATLL by microarray. First in the present study, we analyzed the survival of the patients in relation to expression of c-Met and HGF in ATLL cells. Expression of the former but not the latter was associated with poor prognosis. Then, we analyzed the growth of ATLL cells caused by HGF and c-Met. c-Met was expressed in 0/7 chronic ATLLs, 12/14 acute ATLLs, 1/1 IL-2-independent ATLL cell line and 1/7 IL-2-dependent ATLL cell lines as assessed by flow cytometry. HGF induced the proliferation of primary cells from most acute cases examined as well as the c-Met-positive KK1 cell line in contrast to c-Met-negative cells. HGF induced autophosphorylation of c-Met in c-Met-positive cells from an acute case and KK1 cells. The plasma level of HGF was elevated in acute as compared to chronic cases. The levels of HGF and/or IL-6 which induces the production of HGF by stromal cells, were elevated in the supernatant of short-term cultured cells from certain patients with acute or chronic disease. Finally, infiltrated ATLL cells and adjacent stromal cells in liver were shown to be positive for c-Met/HGF and HGF, respectively, in acute cases. Autocrine and/or paracrine growth caused by HGF and c-Met was suggested in aggressive ATLL cells secreting HGF and/or IL-6, respectively. | |||||
書誌情報 |
International Journal of Oncology 巻 33, 号 4, p. 697-703, 発行日 2008-10 |
|||||
出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10196439 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17912423 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10992511 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18813782 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ijo_00000055 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Oncology, 33(4), pp.697-703; 2008 |