WEKO3
アイテム
{"_buckets": {"deposit": "0e28ea98-298a-48d9-83bd-b16aeb939a2e"}, "_deposit": {"created_by": 2, "id": "16654", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16654"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016654", "sets": ["9"]}, "author_link": ["63889", "63893", "63895", "63891", "63894", "63890", "63892"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "67", "bibliographicPageStart": "61", "bibliographicVolumeNumber": "39", "bibliographic_titles": [{"bibliographic_title": "International journal of oral and maxillofacial surgery"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "alpha-actinin-4, originally identified as an actin-binding protein associated with cell motility, invasion, and metastasis of cancer cells, appears to be overexpressed in various human epithelial carcinomas, including colorectal, breast, esophageal, ovarian, and non-small cell lung carcinomas. The authors evaluated whether alpha-actinin-4 might be appropriate as a molecular target for cancer gene therapy. In 64 primary oral squamous cell carcinomas (OSCCs) and 10 normal oral mucosal specimens, and in seven human OSCC cell lines, alpha-actinin-4 expression was evaluated immunologically and correlations with clinicopathologic factors were examined. Overexpression of alpha-actinin-4 was detected in 38 of 64 oral squamous cell carcinomas (70%); significantly more frequently than in normal oral mucosa. The expression of alpha-actinin-4 was significantly associated with invasion potential defined by the Matrigel invasion assay. Cancer cell lines with higher alpha-actinin-4 expression had greater invasive potential. An RNAi-mediated decrease in alpha-actinin-4 expression reduced the invasion potential. These results indicated that the overexpression of alpha-actinin-4 was associated with an aggressive phenotype of OSCC. The study indicated that alpha-actinin-4 could be a potential molecular target for gene therapy by RNAi targeting for OSCC.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "International journal of oral and maxillofacial surgery, 39(1), pp.61-67; 2010", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Ltd."}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "19913389", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.ijom.2009.10.003", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright c 2009 International Association of Oral and Maxillofacial Surgeons Published by Elsevier Ltd."}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10682150", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09015027", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1399-0020", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamada, Shin-ichi"}], "nameIdentifiers": [{"nameIdentifier": "63889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanamoto, Souichi"}], "nameIdentifiers": [{"nameIdentifier": "63890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Hajime"}], "nameIdentifiers": [{"nameIdentifier": "63891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshitomi, Izumi"}], "nameIdentifiers": [{"nameIdentifier": "63892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawasaki, Goro"}], "nameIdentifiers": [{"nameIdentifier": "63893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuno, Akio"}], "nameIdentifiers": [{"nameIdentifier": "63894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nemoto, Takayuki K."}], "nameIdentifiers": [{"nameIdentifier": "63895", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "IJOMS39_61.pdf", "filesize": [{"value": "836.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 836200.0, "url": {"label": "IJOMS39_61.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16654/files/IJOMS39_61.pdf"}, "version_id": "c445cdee-49f4-4132-af8d-b4f51bf493cf"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "α-actinin-4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "invasion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "metastasis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oral squamous cell carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RNA interference", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma."}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/22538", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-12-04"}, "publish_date": "2009-12-04", "publish_status": "0", "recid": "16654", "relation": {}, "relation_version_is_last": true, "title": ["RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma."], "weko_shared_id": -1}
RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.
http://hdl.handle.net/10069/22538
http://hdl.handle.net/10069/2253838a2e9b2-20bc-476c-bf13-98a93e5e89e1
名前 / ファイル | ライセンス | アクション |
---|---|---|
IJOMS39_61.pdf (836.2 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-12-04 | |||||
タイトル | ||||||
タイトル | RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α-actinin-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | invasion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metastasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oral squamous cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RNA interference | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamada, Shin-ichi
× Yamada, Shin-ichi× Yanamoto, Souichi× Yoshida, Hajime× Yoshitomi, Izumi× Kawasaki, Goro× Mizuno, Akio× Nemoto, Takayuki K. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | alpha-actinin-4, originally identified as an actin-binding protein associated with cell motility, invasion, and metastasis of cancer cells, appears to be overexpressed in various human epithelial carcinomas, including colorectal, breast, esophageal, ovarian, and non-small cell lung carcinomas. The authors evaluated whether alpha-actinin-4 might be appropriate as a molecular target for cancer gene therapy. In 64 primary oral squamous cell carcinomas (OSCCs) and 10 normal oral mucosal specimens, and in seven human OSCC cell lines, alpha-actinin-4 expression was evaluated immunologically and correlations with clinicopathologic factors were examined. Overexpression of alpha-actinin-4 was detected in 38 of 64 oral squamous cell carcinomas (70%); significantly more frequently than in normal oral mucosa. The expression of alpha-actinin-4 was significantly associated with invasion potential defined by the Matrigel invasion assay. Cancer cell lines with higher alpha-actinin-4 expression had greater invasive potential. An RNAi-mediated decrease in alpha-actinin-4 expression reduced the invasion potential. These results indicated that the overexpression of alpha-actinin-4 was associated with an aggressive phenotype of OSCC. The study indicated that alpha-actinin-4 could be a potential molecular target for gene therapy by RNAi targeting for OSCC. | |||||
書誌情報 |
International journal of oral and maxillofacial surgery 巻 39, 号 1, p. 61-67, 発行日 2010-01 |
|||||
出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09015027 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1399-0020 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10682150 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19913389 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijom.2009.10.003 | |||||
権利 | ||||||
権利情報 | Copyright c 2009 International Association of Oral and Maxillofacial Surgeons Published by Elsevier Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International journal of oral and maxillofacial surgery, 39(1), pp.61-67; 2010 |