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Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles
http://hdl.handle.net/10069/38944
http://hdl.handle.net/10069/3894476702143-9c74-4b30-be78-6dba04b3d73b
名前 / ファイル | ライセンス | アクション |
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JCR302_42_SI.pdf (689.6 kB)
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JCR302_42.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-28 | |||||
タイトル | ||||||
タイトル | Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Superoxide dismutase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Paclitaxel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RGD peptide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcium carbonate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lipid nanoparticles | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Peng, Jian Qing
× Peng, Jian Qing× Fumoto, Shintaro× Suga, Tadaharu× Miyamoto, Hirotaka× Kuroda, Naotaka× Kawakami, Shigeru× Nishida, Koyo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Synchronized bio-distribution of combination therapies has several merits such as synergistic effects and reduced side-effects. Co-delivery of a protein and small molecule drug using a single nanocarrier is challenging because they possess totally different characteristics. Herein, we report the development of sophisticated nanoparticles composed of lipids, calcium carbonate and RGD peptide ligands for the co-delivery of a protein and small molecule drug combination via a simple preparation method. A ‘one-step’ ethanol injection method was employed to prepare the highly organized nanoparticles. The nanoparticles exhibited a spherical shape with ca. 130?nm diameter, and clearly had an integrated lipid layer covering the periphery. As a ligand, an RGD-modified lipid was post-inserted into the nanoparticles, which was important to overcome the ‘PEG dilemma’. The pH-sensitivity of the targeted nanoparticles contributed to the efficient intracellular co-delivery of a protein and drug combination in Colon26 tumor cells, and noticeably improved their accumulation in the tumor region of xenograft mice. Synchronized bio-distribution of the protein and drug was achieved, which was the foundation for the synergistic effects of the combination. The targeting capability of the nanoparticles along with their pH-sensitive drug release and the synchronized bio-distribution of their cargos led to the significant antitumor activity of the SOD and paclitaxel combination in mice. This study provides novel information for the design and preparation of functionalized nanoparticles for the delivery of a protein/drug combination in vivo. | |||||
書誌情報 |
Journal of Controlled Release 巻 302, p. 42-53, 発行日 2019-03-28 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01683659 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jconrel.2019.03.021 | |||||
権利 | ||||||
権利情報 | c2019, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Controlled Release, 302, pp.42-53; 2019 |