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抗ラ氏島抗体(ICA)陽性長期罹病インスリン依存型糖尿病患者における64KD抗体
http://hdl.handle.net/10069/22597
http://hdl.handle.net/10069/22597bb20a0b0-fc9f-49ce-92e1-7f273962d88b
名前 / ファイル | ライセンス | アクション |
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tonyobyo35_885.pdf (483.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-07 | |||||
タイトル | ||||||
タイトル | 抗ラ氏島抗体(ICA)陽性長期罹病インスリン依存型糖尿病患者における64KD抗体 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 64KD抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗ラ氏島抗体(ICA) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インスリン依存型糖尿病(IDDM) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 長期罹病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 自己免疫性甲状腺疾患(AITD) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
川崎, 英二
× 川崎, 英二× 瀧野, 博文× 魚谷, 茂雄× 奥野, 信一郎× 高尾, 幸男× 横田, 厚× 赤澤, 昭一× 長瀧, 重信 |
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著者別名 | ||||||
姓名 | Kawasaki, Eiji | |||||
著者別名 | ||||||
姓名 | Takino, Hirofumi | |||||
著者別名 | ||||||
姓名 | Uotani, Shigeo | |||||
著者別名 | ||||||
姓名 | Okuno, Shinichiro | |||||
著者別名 | ||||||
姓名 | Takao, Yukio | |||||
著者別名 | ||||||
姓名 | Yokota, Yukio | |||||
著者別名 | ||||||
姓名 | Akazawa, Shoichi | |||||
著者別名 | ||||||
姓名 | Nagataki, Shigenobu | |||||
その他のタイトル | ||||||
その他のタイトル | Autoantibodies to 64 KD Islet Cell Protein in Long-Standing IDDM Patients with Positive ICA | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | インスリン依存型糖尿病(IDDM)発症後5年以上経過した48例について,抗ラ氏島抗体(ICA)および64KD抗体を測定し,ICA陽性長期罹病IDDM患者における64KD抗体を検討した. 対象48例中17例(35.4%)がICA陽性であった. ICA陽性IDDMは,発症年齢が28.1±13.5歳とICA陰性IDDM(17.3±10.6歳)に比べ有意に高かった(p<0.05). ICA陽性IDDM17例中12例が抗マイクロゾーム抗体陽性で,ICA陰性IDDM(31例中10例)に比べ有意に多く,またICA陽性IDDMは自己免疫性甲状腺疾患(AITD)の合併がICA陰性IDDMに比べ有意に多かった(17例中12例vs31例中8例;p<0.01). 対象46例において64KD抗体を測定した. ICA陽性IDDM 15例中15例,ICA陰性IDDM31例中3例に64KD抗体を認め,その陽性率はICA陽性IDDMに有意に高かった(p<0.001). また,ICAの抗体価の高い症例ほど64KD抗体のレベルも高い傾向を示した. ICA陽性長期罹病IDDMは64KD抗体も陽性を示しており,IDDMのひとつのサブタイプを形成すると考えられる. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To investigate the clinical significance of autoantibodies to 64,000-Mr islet cell protein (64 K antibodies) in patients with long-standing insulin-dependent diabetes mellitus (IDDM) with positive islet cell antibodies (ICA), ICA and 64 K antibodies were assayed in 48 IDDM patients with a disease duration of more than 5 years. ICA were detected in 17 (35.4%) of 48 IDDM patients. Ages at onset of ICA positive IDDM (28.1 ± 13.5 y.o.) were significantly higher than those of ICA negative patients (17.3±10.3 y.o.). The prevalence of autoimmune thyroid disease (AITD) in ICA positive patients was significantly higher than that in ICA negative patients (12/17 vs 8/31 ; p < 0.01). 64 K antibodies were detected in 15 of 15 ICA positive patients and 3 of 31 ICA negative patients, and the prevalence of patients positive for 64 K antibodies was significantly higher in ICA positive patients (p<0.001). In ICA positive patients, the higher levels of 64 K antibodies were observed in patients who had higher ICA titer. These results demonstrate that long-standing IDDM patients with positive ICA were also positive for 64 K antibodies, and this patient group may compose a subtype of IDDM. | |||||
書誌情報 |
糖尿病 en : Journal of the Japan Diabetes Society 巻 35, 号 11, p. 885-891, 発行日 1992-11 |
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出版者 | ||||||
出版者 | 日本糖尿病学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021437X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00166576 | |||||
権利 | ||||||
権利情報 | Copyright (c) 日本糖尿病学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 糖尿病, 35(11), pp. 885-891; 1992 |