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インスリン依存型糖尿病における64KD抗体とglutamic acid decarboxylase の関連について
http://hdl.handle.net/10069/22598
http://hdl.handle.net/10069/22598928c03ca-88a9-4e35-b86c-523e9a2fbfdf
名前 / ファイル | ライセンス | アクション |
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tonyobyo36_507.pdf (338.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-07 | |||||
タイトル | ||||||
タイトル | インスリン依存型糖尿病における64KD抗体とglutamic acid decarboxylase の関連について | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 64KD抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glutamic acid decarboxylase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インスリン依存型糖尿病(IDDM) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
川崎, 英二
× 川崎, 英二× 渡部, 素生× 斎藤, 和子× 矢野, まゆみ× 瀧野, 博文× 魚谷, 茂雄× 松本, 一成× 奥野, 信一郎× 高尾, 幸男× 横田, 厚× 山口, 義彦× 赤津, 昭一× 長瀧, 重信 |
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著者別名 | ||||||
姓名 | Kawasaki, Eiji | |||||
著者別名 | ||||||
姓名 | Watanabe, Motoo | |||||
著者別名 | ||||||
姓名 | Saitoh, Kazuko | |||||
著者別名 | ||||||
姓名 | Yano, Mayumi | |||||
著者別名 | ||||||
姓名 | Takino, Hirofumi | |||||
著者別名 | ||||||
姓名 | Uotani, Shigeo | |||||
著者別名 | ||||||
姓名 | Matsumoto, Kazunari | |||||
著者別名 | ||||||
姓名 | Okuno, Shinichiro | |||||
著者別名 | ||||||
姓名 | Takao, Yukio | |||||
著者別名 | ||||||
姓名 | Yokota, Atsushi | |||||
著者別名 | ||||||
姓名 | Yamaguchi, Yoshihiko | |||||
著者別名 | ||||||
姓名 | Akazawa, Shoichi | |||||
著者別名 | ||||||
姓名 | Nagataki, Shigenobu | |||||
その他のタイトル | ||||||
その他のタイトル | Relationship between 64K Antibodies and Glutamic Acid Decarboxylase in Insulin-Dependent Diabetes | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 64KD抗体陽性インスリン依存型糖尿病(IDDM)患者10例(男性4例,女性6例)において,64KD抗体とその対応抗原と言われているGABA合成酵素glutamic acid decarboxylase(GAD)との反応性を^35S-methionine標識 rat isletを用いた免疫沈降法における吸収試験によって検討した. GADは,2つのisoform(GAD_65,GAD_67)を含むrat brain GADとrecombinant rat GAD_67を用いた. 10例中7例(70.0%)において64kDaのバンドはrecombinant rat GAD_67では吸収されず,rat brain GADで完全に吸収された. また,1例(10.0%)においてrecombinant rat GAD_67でのみ若干の吸収を認め,2例(20.0%)ではrecombinant rat GAD_67,rat brain GADのいずれにおいても吸収されなかった. IDDM患者血中に存在する64KD抗体は,ほとんどの症例においてGAD_65を認識することが示唆されるが,GADを認識しない症例も認められ,このことは64KD抗体が不均一であることを示している. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In 10 of 64K antibody-positive sera from patients with insulin-dependent diabetes mellitus(IDDM), we examined the relationship between 64K antibodies and glutamic acid decarboxylase(GAD), which is the target antigen of these autoantibodies, with an immunoadsorption test using immunoprecipitation of 35S-methionine-labeled rat islet protein. Rat brain GAD containing two isoforms of GAD (GAD65 and GAD67), and recombinant rat GAD67 , were studied. Of these 10 individuals, 7 (70%) showed completely blocked immunoadsorption of the 64K autoantigen only by rat brain GAD, 1 (10%) partial blockage with recombinant rat GAD67 and 2 (20%) showed no blockage with either GAD. These results suggest that most 64 K antibody-positive IDDM recognize GAD65 and that there is heterogeneity of 64 K antibodies. | |||||
書誌情報 |
糖尿病 en : Journal of the Japan Diabetes Society 巻 36, 号 7, p. 507-513, 発行日 1993-07 |
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出版者 | ||||||
出版者 | 日本糖尿病学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021437X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00166576 | |||||
権利 | ||||||
権利情報 | Copyright (c) 日本糖尿病学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 糖尿病, 36(7), pp. 507-513; 1993 |