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Localization of HSP47 mRNA in murine bleomycin-induced pulmonary fibrosis.
http://hdl.handle.net/10069/22906
http://hdl.handle.net/10069/22906ccf7b56f-7e87-48f1-94c2-335e9fdeb8f9
名前 / ファイル | ライセンス | アクション |
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VirArc_Kakugawa.pdf (5.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-10 | |||||
タイトル | ||||||
タイトル | Localization of HSP47 mRNA in murine bleomycin-induced pulmonary fibrosis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Heat shock protein 47 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | In situ hybridization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary fibrosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kakugawa, Tomoyuki
× Kakugawa, Tomoyuki× Mukae, Hiroshi× Hishikawa, Yoshitaka× Ishii, Hiroshi× Sakamoto, Noriho× Ishimatsu, Yuji× Fujii, Takeshi× Koji, Takehiko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that has been shown to play a major role in the processing and/or secretion of procollagen. However, the knowledge on which cells are actually synthesizing HSP47 in the lung parenchyma in pulmonary fibrosis was only limited. The aim of the present study was to investigate the localization of HSP47 messenger ribonucleic acid (mRNA) in normal lung and in the lungs of mice in bleomycin-induced pulmonary fibrosis, using in situ hybridization. For the purpose, ICR mice were intravenously injected with 10 mg/kg per day of bleomycin for five consecutive days. The lung cells expressing HSP47 mRNA were identified in control (saline alone) and bleomycin-treated mice by in situ hybridization. The signal for HSP47 mRNA was markedly increased in bleomycin-treated lungs compared with that of controls. HSP47 mRNA was localized in alpha-smooth-muscle-actin-positive myofibroblasts, surfactant-protein-A-positive type II pneumocytes, and F4/80-positive macrophages in the active fibrotic areas. These results suggest that these cells may synthesize procollagen in the fibrotic process of bleomycin-treated lungs through upregulation of HSP47 mRNA and play an important role in fibrogenesis. | |||||
書誌情報 |
Virchows Archiv : an international journal of pathology 巻 456, 号 3, p. 309-315, 発行日 2010-03 |
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出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09456317 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1432-2307 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10992872 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20094730 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00428-009-0876-x | |||||
権利 | ||||||
権利情報 | c Springer-Verlag 2010 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Virchows Archiv, 456(3), pp.309-315; 2010 |