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Scenario of the twins with suspected congenital rubella syndrome (CRS) in Yangon, Myanmar
http://hdl.handle.net/10069/21524
http://hdl.handle.net/10069/21524d891a476-c4e5-476e-b352-9881f41a96b5
名前 / ファイル | ライセンス | アクション |
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TMH35_271.pdf (49.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-09 | |||||
タイトル | ||||||
タイトル | Scenario of the twins with suspected congenital rubella syndrome (CRS) in Yangon, Myanmar | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myanmar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Congenital rubella syndrome (CRS) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Twins | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Thant, Kyaw-Zin
× Thant, Kyaw-Zin× Thein, Aye-Aye× Myint, San-San× Myint, Thein-Thein× Katow, Shigetaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Rubella is a common cause of childhood rash and fever. Congenital rubella syndrome (CRS) can lead to deafness, heart disease, cataracts, and a variety of other permanent manifestations. In order to identify the disease burden of rubella infection, CRS surveillance among infants in Yangon was conducted for two consecutive years from December 2000 to December 2002, as a WHO-funded study. Among the 13 participating hospitals, the Special Care Baby Unit of the Central Women‘s Hospital in Yangon reported 17 infants with suspected CRS. Interestingly, three sets of twins with suspected CRS were reported. One ml of blood was collected from each infant after obtaining informed consent, then tested for the presence of rubella antibody (Immunoglobulin M and G) by the ELISA method, and for the presence of rubella viral RNA by the RT-PCR method. Furthermore, nucleotide sequencing and genotype identification of samples from two cases with positive rubella RNA were performed. All 3 sets of twins were IgM negative. However, rubella RNA was detected by RT-PCR in twin 1A who showed no obvious clinical signs, and in twin 2B who had patent ductus arteriosus, splenomegaly and hepatomegaly. Nucleotide sequences of PCR positive cases revealed genotype Ia sequences. Twin 2B was identified as having deafness of the left ear on audiometry assessment conducted at 5 years and 4 months of age. Both twins of twin set-2 were IgG positive at age 12 days, but turned out to be negative by the age of 9 months. Both twins of twin set-3 presented with splenomegaly and died before 2 months of age, probably due to other infections. Our findings revealed the different scenario of twins with suspected CRS. It is expected to serve as a valuable addition to the medical literature as there were very few reports on twins with CRS. | |||||
書誌情報 |
Tropical medicine and health 巻 35, 号 3, p. 271-276, 発行日 2007-09 |
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出版者 | ||||||
出版者 | 日本熱帯医学会 | |||||
出版者 | ||||||
出版者 | The Japanese Society of Tropical Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13488945 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11912857 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2149/tmh.35.271 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2007 日本熱帯医学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health Vol. 35 No. 3, 2007, pp. 271-276 |