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OBJECTIVES: The present study was designed to determine the effects of primary and secondary low-grade RSV infections on pulmonary dendritic cell (DC) functions. METHODS: Eight groups of BALB/c mice were used: one group each for control primary and secondary sensitization, primary and secondary sensitization to Dermatophagoides farinae (Derf) allergen, primary and secondary infection with RSV, and primary and secondary sensitization to Derf plus infection with RSV. CD11c+ pulmonary DCs were isolated from these mice and then transferred to naive mice followed by intranasal Derf challenge. Furthermore, either anti-IL-12 monoclonal antibody (alphaIL-12 mAb) or anti-IL-10 (alphaIL-10) mAb were injected into donor mice after Derf challenge and during RSV infection to determine the involvement of IL-12 and IL-10. RESULTS: Primary RSV infection failed to induce polarization in DCs since it failed to induce IL-10 and IL-12 production in Derf-sensitized donor lung. 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Effects of repeated respiratory syncytial virus infections on pulmonary dendritic cells in a murine model of allergic asthma.
http://hdl.handle.net/10069/20172
http://hdl.handle.net/10069/20172d66b481c-ffac-4a02-a9d7-d287d88711fb
名前 / ファイル | ライセンス | アクション |
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IAAI147_197.pdf (251.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-11-14 | |||||
タイトル | ||||||
タイトル | Effects of repeated respiratory syncytial virus infections on pulmonary dendritic cells in a murine model of allergic asthma. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | airway inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | asthma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dendritic cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | respiratory syncytial virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-12 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dermatophagoides farinae | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hirose, Hiroko
× Hirose, Hiroko× Matsuse, Hiroto× Fukahori, Susumu× Tsuchida, Tomoko× Tomari, Shinya× Kawano, Tetsuya× Fukushima, Chizu× Mizuta, Yohei× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Primary and secondary respiratory syncytial virus (RSV) infection differentially regulates preexisting allergic airway inflammation. OBJECTIVES: The present study was designed to determine the effects of primary and secondary low-grade RSV infections on pulmonary dendritic cell (DC) functions. METHODS: Eight groups of BALB/c mice were used: one group each for control primary and secondary sensitization, primary and secondary sensitization to Dermatophagoides farinae (Derf) allergen, primary and secondary infection with RSV, and primary and secondary sensitization to Derf plus infection with RSV. CD11c+ pulmonary DCs were isolated from these mice and then transferred to naive mice followed by intranasal Derf challenge. Furthermore, either anti-IL-12 monoclonal antibody (alphaIL-12 mAb) or anti-IL-10 (alphaIL-10) mAb were injected into donor mice after Derf challenge and during RSV infection to determine the involvement of IL-12 and IL-10. RESULTS: Primary RSV infection failed to induce polarization in DCs since it failed to induce IL-10 and IL-12 production in Derf-sensitized donor lung. In contrast, secondary RSV infection significantly enhanced IL-12 production from Derf-sensitized donor lung, thereby enhancing both Th1 and Th2 responses. During RSV infection, alphaIL-12 but not alphaIL-10 mAb treatment blocked these immunological effects. CONCLUSION: Via IL-12, DCs may play a critical role in shifting the immune response in this experimental model of repeated respiratory viral infection in allergic asthma. | |||||
書誌情報 |
International archives of allergy and immunology 巻 147, 号 3, p. 197-205, 発行日 2008-10 |
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出版者 | ||||||
出版者 | S. Karger AG | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14230097 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10838704 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18594149 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1159/000142042 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 S. Karger AG, Basel. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Archives of Allergy and Immunology, 147(3), pp.197-205; 2008 |