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Lung fibrosis 10 years after cessation of bleomycin therapy.
http://hdl.handle.net/10069/20698
http://hdl.handle.net/10069/20698af816087-50fb-4304-b5dc-1a2c1b573287
名前 / ファイル | ライセンス | アクション |
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Tohoku J.Exp.Med 216 1 77.pdf (663.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-11-21 | |||||
タイトル | ||||||
タイトル | Lung fibrosis 10 years after cessation of bleomycin therapy. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bleomycin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Child | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pneumonitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pneumothorax | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tashiro, Masato
× Tashiro, Masato× Izumikawa, Koichi× Yoshioka, Daisuke× Nakamura, Shigeki× Kurihara, Shintaro× Sakamoto, Noriho× Seki, Masafumi× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Yanagihara, Katunori× Mukae, Hiroshi× Hayashi, Tomayoshi× Fukushima, Kiyoyasu× Tashiro, Takayoshi× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bleomycin (BLM) is a chemotherapeutic agent used for the treatment of several types of malignancy, including germ cell tumors, lymphoma, and certain types of squamous-cell carcinoma. The common adverse effect of BLM is interstitial pneumonitis, followed by pulmonary fibrosis. BLM-induced pneumonitis occurs in up to 46% of patients treated with BLM-containing chemotherapy and lung toxicity usually appears during treatment. Here we describe a patient with lung fibrosis, who presented with slow progressive breathlessness and pneumothorax more than 10 years after cessation of BLM therapy. A 15 year-old girl presented with abnormal shadows on chest X-ray. The patient had a yolk sac carcinoma in the sacral region at 1 year of age and obtained complete remission after being treated with tumor resection, radiation, and several anti-cancer drugs including BLM. There were no abnormal findings in chest X-ray until she reached 3 years of age, when she had developed respiratory distress that worsened with age. The patient had experienced an episode of pneumothorax at 13 years of age. Chest CT at the time revealed interstitial reticular opacities. Radiological findings and pathological examination of the lung tissue obtained during bullectomy with video-assisted thoracic surgery were compatible with BLM-induced pneumonitis. The present study suggests that lung fibrosis may surface more than 10 years after cessation of BLM therapy at the age of 1 year, with no chest radiographic findings 1 year after completion of chemotherapy. The use of BLM in infants requires strict supervision and observation and careful long-term follow up. | |||||
書誌情報 |
The Tohoku journal of experimental medicine 巻 216, 号 1, p. 77-80, 発行日 2008-09 |
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出版者 | ||||||
出版者 | TOHOKU UNIVERSITY MEDICAL PRESS | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-3329 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18719341 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.216.77 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 TOHOKU UNIVERSITY MEDICAL PRESS. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Tohoku Journal of Experimental Medicine 216(1), pp.77-80; 2008 |