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Transfer profile of intramuscularly administered tetrodotoxin to non-toxic cultured specimens of the pufferfish Takifugu rubripes.
http://hdl.handle.net/10069/20800
http://hdl.handle.net/10069/20800bc76001a-7e5b-4076-84e2-0fda85a83432
名前 / ファイル | ライセンス | アクション |
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Toxicon53_99.pdf (199.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-12-10 | |||||
タイトル | ||||||
タイトル | Transfer profile of intramuscularly administered tetrodotoxin to non-toxic cultured specimens of the pufferfish Takifugu rubripes. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunohistochemical observation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intramuscular administration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pufferfish | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Takifugu rubripes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tetrodotoxin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ikeda, Koichi
× Ikeda, Koichi× Murakami, Yumi× Emoto, Yu× Ngy, Laymithuna× Taniyama, Shigeto× Yagi, Motoaki× Takatani, Tomohiro× Arakawa, Osamu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Tetrodotoxin (TTX) was intramuscularly administered to non-toxic cultured specimens of the pufferfish Takifugu rubripes to investigate TTX transfer/accumulation profiles in the pufferfish body. In two groups of test fish administered either 50MU/individual of TTX standard (purified TTX; PTTX) or crude extract of toxic pufferfish ovary (crude TTX; CTTX), TTX rapidly transferred from the muscle via the blood to other organs. The toxin transfer profiles differed between groups, however, from 4 to 72h. In the PTTX group, little TTX was retained in the liver, and most (>96%) of the toxin remaining in the body transferred/accumulated in the skin after 12h, whereas in the CTTX group, a considerable amount of toxin (15%-23% of the administered toxin or 28%-58% of the remaining toxin) was transferred/retained in the liver for up to 24h, despite the fact that 89% of the remaining toxin transferred/accumulated in the skin at the end of rearing period (168h). The total amount of toxin remaining in the entire body at 1-4h was approximately 60% of the administered toxin in both groups, which decreased at 8-12h, and then increased again to approximately 60%-80% at 24-168h. Immunohistochemical observation revealed that the toxin accumulated in the skin was localized at the basal cells of the epidermal layer. | |||||
書誌情報 |
Toxicon : official journal of the International Society on Toxinology 巻 53, 号 1, p. 99-103, 発行日 2009-01 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00410101 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00864479 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18996407 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.toxicon.2008.10.018 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Toxicon, 53(1), pp.99-103; 2009 |