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Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice.
http://hdl.handle.net/10069/21877
http://hdl.handle.net/10069/218772c86a7d7-307a-4923-8667-f2906158a958
名前 / ファイル | ライセンス | アクション |
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CEI152_364.pdf (384.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-05-15 | |||||
タイトル | ||||||
タイトル | Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alpha-1 antitrypsin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | co-infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neutrophil elastase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myeloperoxidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lysozyme | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kosai, Kosuke
× Kosai, Kosuke× Seki, Masafumi× Yanagihara, Katsunori× Nakamura, Shigeki× Kurihara, Shintaro× Imamura, Yoshifumi× Izumikawa, Koichi× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Tashiro, Takayoshi× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Severe pneumonia is found in simultaneous influenza pneumonia and bacterial infection, and suggests a relationship with immunological mechanisms. Here, we performed two-dimensional gel electrophoresis to detect immunological molecules related to the fulminant pneumonia caused by influenza virus and Streptococcus pneumoniae co-infection in mice. We found two spots that were expressed strongly in co-infected mouse lungs, compared with S. pneumoniae or influenza virus singly infected mouse lungs. The spots were analysed by mass spectrometry, and identified as alpha-1 anti-trypsin (A1AT), known as an anti-protease for neutrophil-derived proteolytic enzymes, and creatine kinase, which reflects a greater degree of lung damage and cell death. A1AT expression was increased significantly, and proteolytic enzymes from neutrophils, such as neutrophil elastase, myeloperoxidase and lysozyme, were also secreted abundantly in influenza virus and S. pneumoniae co-infected lungs compared with S. pneumoniae or influenza virus singly infected lungs. These data suggest that A1AT may play a central role as a molecule with broad anti-inflammatory properties, and regulation of the neutrophil-mediated severe lung inflammation is important in the pathogenesis of co-infection with influenza virus and bacteria. | |||||
書誌情報 |
Clinical and experimental immunology 巻 152, 号 2, p. 364-371, 発行日 2008-05 |
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出版者 | ||||||
出版者 | Wiley-Blackwell | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13652249 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11619105 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18341613 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1365-2249.2008.03631.x | |||||
権利 | ||||||
権利情報 | Journal Compilation c 2008 British Society for Immunology | |||||
権利 | ||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clinical and Experimental Immunology, 152(2), pp.364-371; 2008 |