WEKO3
アイテム
{"_buckets": {"deposit": "9d08c509-4379-492d-a1fa-349b07f4932e"}, "_deposit": {"created_by": 2, "id": "18989", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "18989"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00018989", "sets": ["26"]}, "author_link": ["77930", "77929", "77925", "77927", "77928", "77926"], "item_2_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Delayed DNA damage and radiation-induced genomic instability"}]}, "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "115", "bibliographicPageStart": "111", "bibliographicVolumeNumber": "27", "bibliographic_titles": [{"bibliographic_title": "環境変異原研究"}, {"bibliographic_title": "Environmental mutagen research communication", "bibliographic_titleLang": "en"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Ionizing radiation induces genomic instability, which is transmitted through many generations after irradiation in the progeny of surviving cells. We have hypothesized that radiation-induced large deletion causes potentially unstable chromosome regions, which are involved in delayed induction of radiation-induced genomic instability. Using phosphorylation-specific antibodies against ATM and histone H2AX, whose phosphorylation is induced by DNA double strand breaks, we detected delayed induction of phosphorylated ATM and H2AX foci in the progeny of X-ray-surviving cells, which indicated delayed induction of DNA double strand breaks. Furthermore, we found delayed chromosomal instability in X chromosomes in clones which contain large deletion involving the HPRT loci. It is suggested that large deletion involving ~Mb region causes unstable chromatin structure, and it results in delayed rearrangement of chromosomes involved. These findings provide the possibility that manifestation of radiation-induced genomic instability results from delayed DNA breaks, i.e., the breaks lead to delayed chromosome rearrangements, delayed cell death etc., many generations after irradiation.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "環境変異原研究, 27(2), pp. 111-115; 2005", "subitem_description_type": "Other"}]}, "item_2_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "77928", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Suzuki, Keiji"}]}, {"nameIdentifiers": [{"nameIdentifier": "77929", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kodama, Seiji"}]}, {"nameIdentifiers": [{"nameIdentifier": "77930", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Watanabe, Masami"}]}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本環境変異原学会"}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "日本環境変異原学会"}, {"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN1006217X", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09100865", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "鈴木, 啓司"}], "nameIdentifiers": [{"nameIdentifier": "77925", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "児玉, 靖司"}], "nameIdentifiers": [{"nameIdentifier": "77926", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "渡邉, 正己"}], "nameIdentifiers": [{"nameIdentifier": "77927", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110001789612.pdf", "filesize": [{"value": "629.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 629000.0, "url": {"label": "110001789612.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/18989/files/110001789612.pdf"}, "version_id": "0a66a9d6-11b5-4019-9887-a6dc025c3569"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "radiation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "genome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "instability", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DNA damage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "chromatin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "遅延性DNA損傷の誘発と遺伝的不安定性", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "遅延性DNA損傷の誘発と遺伝的不安定性"}]}, "item_type_id": "2", "owner": "2", "path": ["26"], "permalink_uri": "http://hdl.handle.net/10069/20815", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-12-15"}, "publish_date": "2008-12-15", "publish_status": "0", "recid": "18989", "relation": {}, "relation_version_is_last": true, "title": ["遅延性DNA損傷の誘発と遺伝的不安定性"], "weko_shared_id": -1}
遅延性DNA損傷の誘発と遺伝的不安定性
http://hdl.handle.net/10069/20815
http://hdl.handle.net/10069/2081534e9a403-1bc1-4105-86da-8647a4ea5b5c
名前 / ファイル | ライセンス | アクション |
---|---|---|
110001789612.pdf (629.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-12-15 | |||||
タイトル | ||||||
タイトル | 遅延性DNA損傷の誘発と遺伝的不安定性 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | instability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA damage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chromatin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
鈴木, 啓司
× 鈴木, 啓司× 児玉, 靖司× 渡邉, 正己 |
|||||
著者別名 | ||||||
姓名 | Suzuki, Keiji | |||||
著者別名 | ||||||
姓名 | Kodama, Seiji | |||||
著者別名 | ||||||
姓名 | Watanabe, Masami | |||||
その他のタイトル | ||||||
その他のタイトル | Delayed DNA damage and radiation-induced genomic instability | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ionizing radiation induces genomic instability, which is transmitted through many generations after irradiation in the progeny of surviving cells. We have hypothesized that radiation-induced large deletion causes potentially unstable chromosome regions, which are involved in delayed induction of radiation-induced genomic instability. Using phosphorylation-specific antibodies against ATM and histone H2AX, whose phosphorylation is induced by DNA double strand breaks, we detected delayed induction of phosphorylated ATM and H2AX foci in the progeny of X-ray-surviving cells, which indicated delayed induction of DNA double strand breaks. Furthermore, we found delayed chromosomal instability in X chromosomes in clones which contain large deletion involving the HPRT loci. It is suggested that large deletion involving ~Mb region causes unstable chromatin structure, and it results in delayed rearrangement of chromosomes involved. These findings provide the possibility that manifestation of radiation-induced genomic instability results from delayed DNA breaks, i.e., the breaks lead to delayed chromosome rearrangements, delayed cell death etc., many generations after irradiation. | |||||
書誌情報 |
環境変異原研究 en : Environmental mutagen research communication 巻 27, 号 2, p. 111-115, 発行日 2005-07 |
|||||
出版者 | ||||||
出版者 | 日本環境変異原学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09100865 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN1006217X | |||||
権利 | ||||||
権利情報 | 日本環境変異原学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 環境変異原研究, 27(2), pp. 111-115; 2005 |