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Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells.
http://hdl.handle.net/10069/20853
http://hdl.handle.net/10069/208539a966139-c306-496b-9966-4b1708069b27
名前 / ファイル | ライセンス | アクション |
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PNAS105_15890_SuppInfo.pdf (362.2 kB)
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PNAS105_15890.pdf (387.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-01-21 | |||||
タイトル | ||||||
タイトル | Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nippostrongyrus brasiliensis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | siRNA | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Honma, Kiri
× Honma, Kiri× Kimura, Daisuke× Tominaga, Norio× Miyakoda, Mana× Matsuyama, Toshifumi× Yui, Katsuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4(+) T cells into Th2 and Th17 cells. Using the infection model of Nippostrongyrus brasiliensis, we have confirmed the critical roles of IRF-4 in Th2 development in vivo by using IRF-4(-/-) BALB/c mice. However, naive IRF-4(-/-)CD4(+) T cells produced Th2 cytokines, including IL-4, IL-5, and IL-10, but not IL-2 or IFN-gamma, at levels higher than wild-type BALB/c CD4(+) T cells in response to T cell receptor stimulation. In contrast, effector/memory IRF-4(-/-)CD4(+) T cells did not exhibit increased production of Th2 cytokines. Knockdown of IRF-4 expression by using small interfering RNA promoted IL-4 production in naive CD4(+) T cells but inhibited it in effector/memory CD4(+) T cells. These results indicate that IRF-4 plays differential roles in the regulation of Th2 cytokine production in naive CD4(+) T cells and effector/memory CD4(+) T cells. IRF-4 inhibits Th2 cytokine production in naive CD4(+) T cells, whereas it promotes Th2 cytokine production in effector/memory CD4(+) T cells. | |||||
書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America 巻 105, 号 41, p. 15890-15895, 発行日 2008-10-14 |
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出版者 | ||||||
出版者 | National Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00278424 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1091-6490 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18836070 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1073/pnas.0803171105 | |||||
権利 | ||||||
権利情報 | (c) 2008 by The National Academy of Sciences of the USA | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Proceedings of the National Academy of Sciences of the United States of America, 105(41), pp.15890-15895; 2008 |