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Dehydroepiandrosterone augments sensitivity to gamma-ray irradiation in human H4 neuroglioma cells through down-regulation of Akt signaling.
http://hdl.handle.net/10069/22531
http://hdl.handle.net/10069/22531688e914b-0a2c-4005-8da7-d894a6ffba0f
名前 / ファイル | ライセンス | アクション |
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FRR42_957.pdf (647.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-03 | |||||
タイトル | ||||||
タイトル | Dehydroepiandrosterone augments sensitivity to gamma-ray irradiation in human H4 neuroglioma cells through down-regulation of Akt signaling. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dehydroepiandrosterone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Akt | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein phosphatase 2A | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hirao, Tomohito
× Hirao, Tomohito× Urata, Yoshishige× Kageyama, Kan× Ikezaki, Midori× Kawakatsu, Miho× Matsuse, Michiko× Matsuo, Takayuki× Akishita, Masahiro× Nagata, Izumi× Kondo, Takahito |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dehydroepiandrosterone (DHEA) modulates sensitivity to radiation-induced injury in human neuroglioma cells (H4) through effects on Akt signalling by glutathione (GSH)-dependent redox regulation. Previous treatment of H4 cells with DHEA for 18 h reduced the gamma-ray-induced phosphorylation of Akt, activated p21(waf1) synthesis and up-regulated phosphorylation of Rb independent of p53. These reactions were followed by a decrease in cell number and an increase in apoptosis and G(2)/M checkpoint arrest. The suppression of phosphorylation of Akt by DHEA was due to regulation of the dephosphorylation by protein phosphatase 2A (PP2A). DHEA up-regulated the expression of gamma-glutamylcysteine synthetase, a rate-limiting enzyme of glutathione (GSH) synthesis, and the levels of GSH to maintain PP2A activity. The results suggested that DHEA increases the sensitivity of cells to gamma-ray irradiation by inducing apoptosis and cell cycle arrest through GSH-dependent regulation of the reduced form of PP2A to down-regulate the Akt signalling pathway. | |||||
書誌情報 |
Free radical research 巻 42, 号 11-12, p. 957-965, 発行日 2008-11 |
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出版者 | ||||||
出版者 | Taylor & Francis | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10715762 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19031317 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/10715760802566582 | |||||
権利 | ||||||
権利情報 | c 2008 Informa plc | |||||
権利 | ||||||
権利情報 | This is an electronic version of an article published in Free Radical Research, 42(11-12), 957-965: 2008 November. Free Radical Research is available online at: http://www.informaworld.com/openurl?genre=article&issn=10715762&volume=42&issue=11&spage=957 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Free Radical Research, 42(11-12), pp.957-965; 2008 |