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Additive effect of pneumococcal vaccine and influenza vaccine on acute exacerbation in patients with chronic lung disease
http://hdl.handle.net/10069/18720
http://hdl.handle.net/10069/187204c242155-2945-4d5d-a453-d5e62d665e25
名前 / ファイル | ライセンス | アクション |
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Vaccine26_4284.pdf (314.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-07-22 | |||||
タイトル | ||||||
タイトル | Additive effect of pneumococcal vaccine and influenza vaccine on acute exacerbation in patients with chronic lung disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute exacerbation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic lung diseases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic obstructive pulmonary diseases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Influenza vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pneumococcal vaccine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Furumoto, Akitsugu
× Furumoto, Akitsugu× Ohkusa, Yasushi× Chen, Meng× Kawakami, Kenji× Masaki, Hironori× Sueyasu, Yoshiko× Iwanaga, Tomoaki× Aizawa, Hisamichi× Nagatake, Tsuyoshi× Oishi, Kazunori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To determine the clinical efficacy of combined vaccination with 23-valent pneumococcal vaccine (PV) and influenza vaccine (IV) against pneumonia and acute exacerbation of chronic lung diseases (CLD), we conducted an open-label, randomized, controlled study among 167 adults with CLD over a 2-year period. Subjects were randomly assigned to a PV + IV group (n = 87) or an IV group (n = 80). The number of patients with CLD experiencing infectious acute exacerbation (P = 0.022), but not pneumonia (P = 0.284), was significantly lower in the PV + IV group compared with the IV group. When these subjects were divided into subgroups, an additive effect of PV with IV in preventing infectious acute exacerbation was significant only in patients with chronic obstructive pulmonary diseases (P = 0.037). In patients with CLD, the Kaplan-Meier survival curves demonstrated a significant difference for infectious acute exacerbation (P = 0.016) between the two groups. An additive effect of PV with IV on infectious acute exacerbation was found during the first year after vaccination (P = 0.019), but not during the second year (P = 0.342), and was associated with serotype-specific immune response in sera of these patients who used PV during the same period. | |||||
書誌情報 |
Vaccine 巻 26, 号 33, p. 4284-4289, 発行日 2008-08-05 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0264410X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1358-8745 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10491877 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.vaccine.2008.05.037 | |||||
権利 | ||||||
権利情報 | Copyright c 2008 Elsevier Ltd All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Vaccine, 26(33), pp.4284-4289; 2008 |