WEKO3
アイテム
{"_buckets": {"deposit": "f36292cd-4be5-489b-8b3b-c371fe592d58"}, "_deposit": {"created_by": 2, "id": "19484", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "19484"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00019484", "sets": ["30"]}, "author_link": ["81353", "81351", "81352", "81350"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "Supplement", "bibliographicPageEnd": "264", "bibliographicPageStart": "261", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Journal of radiation research"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 × g) induced the accumulation of p53 in the human glioblastoma cell line A172 after 3 h of incubation. Low-dose (0.5 Gy) irradiation to the cells accumulated p53 1.5 h after irradiation, and induced Waf-1 and Bax. Under the condition of hypergravity (20 × g), the peak of p53 accumulation was shifted from 1.5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Journal of radiation research. 2002, 43(Supplement), p.261-264", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本放射線影響学会"}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "日本放射線影響学会"}, {"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00705792", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "04493060", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okaichi, Kumio"}], "nameIdentifiers": [{"nameIdentifier": "81350", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Usui, Aya"}], "nameIdentifiers": [{"nameIdentifier": "81351", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohnishi, Takeo"}], "nameIdentifiers": [{"nameIdentifier": "81352", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "81353", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "RR43_S261_264.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "RR43_S261_264.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/19484/files/RR43_S261_264.pdf"}, "version_id": "fafaf9a4-9144-4593-8433-67ca7200df4b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Hypergravity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ionizing radiation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Signal transduction", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/18817", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-08-11"}, "publish_date": "2008-08-11", "publish_status": "0", "recid": "19484", "relation": {}, "relation_version_is_last": true, "title": ["Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53"], "weko_shared_id": -1}
Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53
http://hdl.handle.net/10069/18817
http://hdl.handle.net/10069/18817ac323d43-6a8b-4b24-b2e1-38e19e44a5d1
名前 / ファイル | ライセンス | アクション |
---|---|---|
RR43_S261_264.pdf (2.5 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-08-11 | |||||
タイトル | ||||||
タイトル | Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypergravity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ionizing radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal transduction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Okaichi, Kumio
× Okaichi, Kumio× Usui, Aya× Ohnishi, Takeo× Okumura, Yutaka |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 × g) induced the accumulation of p53 in the human glioblastoma cell line A172 after 3 h of incubation. Low-dose (0.5 Gy) irradiation to the cells accumulated p53 1.5 h after irradiation, and induced Waf-1 and Bax. Under the condition of hypergravity (20 × g), the peak of p53 accumulation was shifted from 1.5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells. | |||||
書誌情報 |
Journal of radiation research 巻 43, 号 Supplement, p. 261-264, 発行日 2002-12 |
|||||
出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 2002, 43(Supplement), p.261-264 |