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Extension of In vitro Life-span of γ-irradiated Human Embryo Cells Accompanied by Chromosome Instability
http://hdl.handle.net/10069/19028
http://hdl.handle.net/10069/19028933c33a8-d637-4521-aeb7-527feb157077
名前 / ファイル | ライセンス | アクション |
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RR39_3_203_213.pdf (536.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-12 | |||||
タイトル | ||||||
タイトル | Extension of In vitro Life-span of γ-irradiated Human Embryo Cells Accompanied by Chromosome Instability | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Low dose γ-rays | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Life-span extension | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chromosome bridge | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chromosome instability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human embryo cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Suzuki, Masao
× Suzuki, Masao× Yang, Zhi× Nakano, Kazushiro× Yatagai, Fumio× Suzuki, Keiji× Kodama, Seiji× Watanabe, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We studied the effect of repeated irradiation with a low dose rate (about 0.0012 cGy per mm) of ^<60> Co γ-rays on the in vitro life-span of human embryo (HE) cells. HE cells were cultured in an incubator that was set in a ^<60>Co γ-ray-irradiation room, and the irradiation was repeated throughout the life-span of the HE cells (for about 150 to 160 days) on every day base. During this period, the cells accumulated 106 to 123 cGy. The life-span of the irradiated cells prolonged 1.14 to 1.35 times when compared to that of non-irradiated cells. The incidence of cells with chromosome bridge and micronuclei significantly increased in the irradiated cells. Although the number of chromosomes gradually changed with repetition of culture in both non-irradiated and irradiated cells, the frequencies of aneuploid cells in irradiated cells were about two times higher than that in non-irradiated cells. These results indicate that repeated irradiation with a low dose of γ-rays produces chromosome instability, and it may be a cause of numerical chromosome abnormalities and life-span extension of irradiated cells. | |||||
書誌情報 |
Journal of radiation research 巻 39, 号 3, p. 203-213, 発行日 1998-09 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 1998, 39(3), p.203-213 |