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Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women
http://hdl.handle.net/10069/39283
http://hdl.handle.net/10069/3928347441d4d-afe7-4864-a0fe-e187e17a0066
名前 / ファイル | ライセンス | アクション |
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CCA495_545.pdf (274.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-05-31 | |||||
タイトル | ||||||
タイトル | Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immune complex antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immune complexome analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | infertility | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spermatogenic dysfunction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spermatogenic dysfunction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endometriosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Murakami, Naoko
× Murakami, Naoko× Kitajima, Michio× Ohyama, Kaname× Aibara, Nozomi× Taniguchi, Ken× Wei, Mian× Kitajima, Yuriko× Miura, Kiyonori× Masuzaki, Hideaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Autoimmune reactions and subsequent inflammation may underlie spermatogenic dysfunction and endometriosis-related infertility.The aim of this study is to identify disease-specific antigens in immune complexes (ICs) in seminal plasma (SP) and in follicular fluid (FF). Methods: Immune complexome analysis, in which nano-liquid chromatography-tandem mass spectrometry is employed to comprehensively identify antigens incorporated into ICs in biological fluids, was performed for specimens collected from infertile couples undergoing assisted reproduction.Forty-two male patients consisting of subjects with oligozoospermia (n=6), asthenozoospermia (n=8), and normal semen analysis (n=28). Fifty-eight female patients consisting of subjects with ovarian endometriosis (n=10) and control women without disease (n=48). Results: Four disease-specific antigens were identified in subjects with oligozoospermia, while five disease-specific antigens were detected in subjects with asthenozoospermia, some of which are involved in sprematogenesis. Eight antigens were detected only in subjects with endometriosis. Conclusion: Functional characteristics of disease-specific antigens were found to correspond to the pathogenesis of male and female infertility. The formation of ICs may contribute to spermatogenic dysfunction and endometriosis-related infertility via loss of function of the related proteins. Immune complexome analysis is expected to be a valuable tool for the investigation of novel diagnostic methods and treatment strategies for infertility. |
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書誌情報 |
Clinica Chimica Acta 巻 495, p. 545-551, 発行日 2019-05-31 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0009-8981 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.cca.2019.05.031 | |||||
権利 | ||||||
権利情報 | c 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clinica Chimica Acta, 495, pp.545-551; 2019 |