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The Efficacy of PAF Antagonist TCV-309 in a Canine Single Lung Allotransplantation after 24 hour . Preservation
http://hdl.handle.net/10069/15986
http://hdl.handle.net/10069/15986dece9cc2-72a9-4a19-91a2-8937055222de
名前 / ファイル | ライセンス | アクション |
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acta39_01_25_t.pdf (882.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | The Efficacy of PAF Antagonist TCV-309 in a Canine Single Lung Allotransplantation after 24 hour . Preservation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Ide, Seiichiro
× Ide, Seiichiro× Kawahara, Katunobu× Takahashi, Takao× Sasaki, Nobuhumi× Shingu, Hiroshi× Yamamoto, Satoshi× Nagayasu, Takeshi× Tomita, Masao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To evaluate the efficacy of TCV-309, platelet activating factor (PAF) antagonist, we investigated the use of this agent when added to the Euro-Collins solution or administered to the donor and the recipient as well as the Euro-Collins solution in the preservation of a canine lung for 24 hours. The function of the graft was assessed before harvesting and one hour after reperfusion by a unilateral pulmonary artery occlusion test. In the ECS group, donor lungs were flushed with 500 ml of the Euro-Collins solution containing 375 μg TCV-309. In the TCV group, donor and recipient dogs were pretreated with TCV-309, and donor lungs were flushed as the ECS group. Donor dogs received TCV-309 100 μg/kg bolus followed by continuous infusion of 500 μg/kg/hr for one hour. Recipient dogs received TCV-309 100 pg/kg bolus followed by continuous infusion of 500 μg/kg/hr for two hours, encompassing two hours of reperfusion. Better posttransplantation pulmonary function was obtained in the TCV group. In conclusion the PAF antagonist TCV-309 is a beneficial agent when it is administered to the donor and the recipient and added to the Euro-Collins solution in a canine model of a single lung transplantation after 24 hr preservation. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 1-3, p. 138-143, 発行日 1994-10-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00138-P00143 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(1-3), p.138-143 |